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Organization of nuclear architecture during adipocyte differentiation

机译：脂肪细胞分化过程中核结构的组织

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Obesity is a serious health problem worldwide since it is a major risk factor for chronic diseases such as type II diabetes. Obesity is the result of hyperplasia (associated with increased adipogenesis) and hypertrophy (associated with decreased adipogenesis) of the adipose tissue. Therefore, understanding the molecular mechanisms underlying the process of adipocyte differentiation is relevant to delineate new therapeutic strategies for treatment of obesity. As in all differentiation processes, temporal patterns of transcription are exquisitely controlled, allowing the acquisition and maintenance of the adipocyte phenotype. The genome is spatially organized; therefore decoding local features of the chromatin language alone does not suffice to understand how cell type-specific gene expression patterns are generated. Elucidating how nuclear architecture is built during the process of adipogenesis is thus an indispensable step to gain insight in how gene expression is regulated to achieve the adipocyte phenotype. Here we will summarize the recent advances in our understanding of the organization of nuclear architecture as progenitor cells differentiate in adipocytes, and the questions that still remained to be answered.
机译：肥胖是全世界范围内严重的健康问题，因为它是II型糖尿病等慢性疾病的主要危险因素。肥胖是脂肪组织增生（与脂肪形成增加有关）和肥大（与脂肪形成减少有关）的结果。因此，了解脂肪细胞分化过程的分子机制与确定新的肥胖治疗策略有关。在所有分化过程中，转录的时间模式都得到了精确控制，从而可以获取和维持脂肪细胞表型。基因组在空间上是有组织的;因此，仅解码染色质语言的局部特征不足以了解如何生成特定于细胞类型的基因表达模式。因此，阐明在脂肪生成过程中如何构建核结构是获得洞悉如何调节基因表达以实现脂肪细胞表型的必不可少的步骤。在这里，我们将总结随着祖细胞在脂肪细胞中分化而对核结构组织的理解的最新进展，以及仍然有待回答的问题。

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