...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >Traffic control at the nuclear pore
【24h】

Traffic control at the nuclear pore

机译：核孔处的交通管制

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The proper communication between organelles is essential for many aspects of eukaryotic life. The coordination of nuclear and cytoplasmic activities in particular is of pivotal importance and depends on transport in and out of the nucleus. The material which translocates through nuclear pores is diverse; it includes numerous proteins, RNAs and large ribonucleoprotein complexes like ribosomal subunits. To ensure the correct nucleocytoplasmic distribution of these components, appropriate mechanisms have to be in place which control traffic across the nuclear envelope. A growing number of studies support the notion that transport through nuclear pore complexes is intimately linked to cell physiology. As such, it has become evident that changes in the cellular environment, either by externally applied stress, aging or disease, alter nuclear traffic. Due to the progress made in the past few years, we are now beginning to understand these processes at the molecular level. Thus, the concept emerges that stress or disease conditions correlate with signaling events which aim at the nuclear transport apparatus. Here, we summarize results from recent publications that provide evidence for the hypothesis that changes in cell physiology modulate nuclear traffic by targeting multiple transport factors. We propose that this traffic control is at least in part mediated by specific signaling events.
机译：细胞器之间的正确交流对于真核生物生活的许多方面至关重要。尤其是核和细胞质活动的协调至关重要，并取决于进出核的转运。通过核孔易位的物质是多种多样的。它包含许多蛋白质，RNA和大型核糖核蛋白复合物（如核糖体亚基）。为了确保这些成分的正确核质分布，必须采用适当的机制来控制跨核膜层的运输。越来越多的研究支持这样一种观念，即通过核孔复合物的转运与细胞生理学密切相关。因此，很明显，细胞环境的变化，无论是外部施加的压力，衰老还是疾病，都会改变核交通。由于过去几年取得的进展，我们现在开始在分子水平上理解这些过程。因此，出现了这样的概念，即压力或疾病状况与针对核运输设备的信号事件相关。在这里，我们总结了最新出版物的结果，这些结果为以下假设提供了证据：细胞生理学的变化通过靶向多种转运因子来调节核交通。我们提出，这种流量控制至少部分地由特定的信令事件来介导。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号