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Assembly and disassembly of the nucleolus during the cell cycle

机译：细胞周期中核仁的组装和拆卸

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The nucleolus is a large nuclear domain in which transcription, maturation and assembly of ribosomes take place. In higher eukaryotes, nucleolar organization in three sub-domains reflects the compartmentation of the machineries related to active or inactive transcription of the ribosomal DNA, ribosomal RNA processing and assembly with ribosomal proteins of the two (40S and 60S) ribosomal subunits. The assembly of the nucleoli during telophase/early G1 depends on pre-existing machineries inactivated during prophase (the transcription machinery and RNP processing complexes) and on partially processed 45S rRNAs inherited throughout mitosis. In telophase, the 45S rRNAs nucleate the prenucleolar bodies and order the dynamics of nucleolar assembly. The assembly/disassembly processes of the nucleolus depend on the equilibrium between phosphorylation/dephosphorylation of the transcription machinery and on the RNP processing complexes under the control of the CDK1-cyclin B kinase and PP1 phosphatases. The dynamics of assembly/disassembly of the nucleolus is time and space regulated.
机译：核仁是一个大的核域，核糖体在其中发生转录，成熟和组装。在高级真核生物中，三个亚结构域中的核仁组织反映了与核糖体DNA的活性或非活性转录，核糖体RNA加工以及两个（40S和60S）核糖体亚基的核糖体蛋白组装有关的机制的分隔。末期/早期G1期间核仁的组装取决于前期（转录机制和RNP加工复合体）失活的先前存在的机械，以及整个有丝分裂中遗传的部分加工的45S rRNA。在末期，45S rRNA使前核仁小体成核并命令核仁装配的动力学。核仁的组装/拆卸过程取决于转录机制的磷酸化/去磷酸化之间的平衡，以及CDK1-cyclin B激酶和PP1磷酸酶控制下的RNP加工复合物。核仁组装/拆卸的动力学是受时间和空间调节的。

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