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Mammalian telomeres and their partnership with lamins

机译：哺乳动物端粒及其与lamins的伙伴关系

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Chromosome ends are complex structures, which require a panel of factors for their elongation, replication, and protection. We describe here the mechanics of mammalian telomeres, dynamics and maintainance in relation to lamins. Multiple biochemical connections, including association of telomeres to the nuclear envelope and matrix, of telomeric proteins to lamins, and of lamin-associated proteins to chromosome ends, underline the interplay between lamins and telomeres. Paths toward senescence, such as defective telomere replication, altered heterochromatin organization, and impaired DNA repair, are common to lamins' and telomeres' dysfunction. The convergence of phenotypes can be interpreted through a model of dynamic, lamin-controlled functional platforms dedicated to the function of telomeres as fragile sites. The features of telomeropathies and laminopathies, and of animal models underline further overlapping aspects, including the alteration of stem cell compartments. We expect that future studies of basic biology and on aging will benefit from the analysis of this telomere-lamina interplay.
机译：染色体末端是复杂的结构，需要一系列因素对其进行延伸，复制和保护。我们在这里描述哺乳动物端粒的力学，动力学和与lamins相关的维护。多种生物化学联系，包括端粒与核膜和基质的缔合，端粒蛋白与核纤层蛋白以及层蛋白相关蛋白与染色体末端的结合，突显了纤体蛋白与端粒之间的相互作用。衰老的途径，例如端粒复制缺陷，异染色质组织改变和DNA修复受损，都是lamins和端粒功能障碍的常见原因。表型的收敛可以通过动态的，层流控制的功能平台模型来解释，这些平台致力于将端粒作为脆弱位点的功能。端粒病和laminopathies的特征以及动物模型的特征突出了进一步的重叠方面，包括干细胞区室的改变。我们希望，对端粒-椎板相互作用的分析将有助于对基础生物学和衰老的进一步研究。

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