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首页> 外文期刊>NPJ vaccines. >Vaccination of domestic animals with a novel oral vaccine prevents Giardia infections, alleviates signs of giardiasis and reduces transmission to humans
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Vaccination of domestic animals with a novel oral vaccine prevents Giardia infections, alleviates signs of giardiasis and reduces transmission to humans

机译：用新型口服疫苗对家畜进行疫苗接种可预防贾第鞭毛虫感染，减轻贾第鞭毛虫病的迹象，并减少向人的传播

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Scientists in Argentina have proposed a candidate for the first vaccine against Giardia infection. Giardia typically escapes vaccination by changing its surface proteins, masking it from detection by the immune system. Hugo Lujan and colleagues at Universidad Católica de Córdoba and Consejo Nacional de Investigaciones Cientificas y Tecnicas overcame this by inducing the parasite to express all of these proteins at the same time, allowing them to craft an oral vaccine against all variations of the infection. Lujan's team tested their vaccine in domestic animals and found that the vaccine both conferred protection against giardiasis and reduced infection in diseased animals. A community with immunized dogs saw a sharp decrease in infected children, highlighting the potential of the vaccine to stem transfer to humans. The researchers suggest this vaccine could be economically produced and endorse research into a human vaccine. Scientists in Argentina have proposed a candidate for the first vaccine against Giardia infection. Giardia typically escapes vaccination by changing its surface proteins, masking it from detection by the immune system. Hugo Lujan and colleagues at Universidad Católica de Córdoba and Consejo Nacional de Investigaciones Cientificas y Tecnicas overcame this by inducing the parasite to express all of these proteins at the same time, allowing them to craft an oral vaccine against all variations of the infection. Lujan's team tested their vaccine in domestic animals and found that the vaccine both conferred protection against giardiasis and reduced infection in diseased animals. A community with immunized dogs saw a sharp decrease in infected children, highlighting the potential of the vaccine to stem transfer to humans. The researchers suggest this vaccine could be economically produced and endorse research into a human vaccine.
机译：阿根廷的科学家已提出第一种抗贾第鞭毛虫感染的疫苗。贾第鞭毛虫通常通过改变其表面蛋白来逃避疫苗接种，从而使其无法被免疫系统检测到。哥斯达黎加天主教大学和西班牙国立研究中心的Hugo Lujan及其同事通过诱导寄生虫同时表达所有这些蛋白质的方法克服了这一问题，从而使他们能够制作针对所有感染变异的口服疫苗。 Lujan的小组在家畜中测试了他们的疫苗，发现该疫苗既可以保护贾第鞭毛虫病，又可以减少患病动物的感染。一个带有免疫犬的社区看到受感染儿童的数量急剧减少，这突出表明了该疫苗阻止向人类转移的潜力。研究人员认为，这种疫苗可以经济地生产，并支持对人类疫苗的研究。阿根廷的科学家已提出第一种抗贾第鞭毛虫感染的疫苗。贾第鞭毛虫通常通过改变其表面蛋白来逃避疫苗接种，从而使其无法被免疫系统检测到。哥斯达黎加天主教大学和西班牙国立研究中心的Hugo Lujan及其同事通过诱导寄生虫同时表达所有这些蛋白质的方法克服了这一问题，从而使他们能够制作针对所有感染变异的口服疫苗。 Lujan的小组在家畜中测试了他们的疫苗，发现该疫苗既可以保护贾第鞭毛虫病，又可以减少患病动物的感染。一个带有免疫犬的社区看到受感染儿童的数量急剧减少，这突出表明了该疫苗阻止向人类转移的潜力。研究人员认为，这种疫苗可以经济地生产，并支持对人类疫苗的研究。

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