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首页> 外文期刊>NPJ vaccines. >Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague
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Immunisation of two rodent species with new live-attenuated mutants of Yersinia pestis CO92 induces protective long-term humoral- and cell-mediated immunity against pneumonic plague

机译：用鼠疫耶尔森菌新的减毒活体突变体对两个啮齿动物进行免疫，可诱导其对肺炎鼠疫的长期体液和细胞介导的免疫保护作用

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Modified Yersinia pestis strains with a favourable safety profile have been shown to confer long-term protection against pneumonic plague. Ashok Chopra and colleagues at the University of Texas genetically modified a strain of Y. pestis—the pathogen causing plague-deleting the genes that allow the bacterium to proliferate in a host and cause disease. Using rat and mouse models, the team found their mutated strains caused no pathogenic symptoms yet generated total immunity when challenged with the live bacteria at 120 days post—immunization, with protected animals expressing significantly higher levels of immune system mediators. The findings call for investigation into the suitability of this vaccine in humans due to the lack of an FDA-approved vaccine for plague, with current vaccines causing severe side effects and death if used by certain individuals.
机译：改良的鼠疫耶尔森氏菌菌株具有良好的安全性，已被证明可以长期预防肺鼠疫。得克萨斯大学的Ashok Chopra及其同事对鼠疫耶尔森氏菌进行了基因改造，该病原体引起瘟疫，删除了使细菌在宿主中繁殖并引起疾病的基因。利用大鼠和小鼠模型，研究小组发现，他们的突变菌株在免疫后120天受到活细菌的攻击时，没有引起致病症状，却没有产生完全的免疫力，受保护的动物表达了更高水平的免疫系统介质。由于缺乏FDA批准的鼠疫疫苗，该发现需要对这种疫苗在人类中的适用性进行调查，目前的疫苗如果被某些人使用会引起严重的副作用和死亡。

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