Defining flexible vs. inherent promoter architectures

Dana J. Huebert; Audrey P. Gasch

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Defining flexible vs. inherent promoter architectures

机译：定义灵活的启动器架构与固有的启动器架构

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The degree to which nucleosome positioning regulates transcription is an ongoing debate. To address this question, we recently followed dynamic changes in nucleosome occupancy, transcription factor binding and gene expression in yeast cells responding to oxidative stress. Integrating across these dynamic processes revealed new insights into the functions of nucleosome reorganization. Here, we used our data to address the extent to which upstream promoter architecture is a static feature inherent to specific genes vs. a dynamic platform that changes across conditions. Our results argue that, while some aspects of promoter architecture are fixed across environments, the level to which promoters are “open” or “covered” by nucleosomes depends on the conditions investigated.

机译：核小体定位调节转录的程度是一个持续的争论。为了解决这个问题，我们最近跟踪了响应氧化应激的酵母细胞中核小体占据，转录因子结合和基因表达的动态变化。这些动态过程的整合揭示了对核小体重组功能的新见解。在这里，我们使用我们的数据来解决上游启动子结构是特定基因固有的静态特征相对于随条件变化的动态平台的程度。我们的结果认为，尽管启动子结构的某些方面在整个环境中都是固定的，但启动子被核小体“开放”或“覆盖”的水平取决于所研究的条件。

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《Nucleus》 |2012年第5期|共5页
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Dana J. Huebert; Audrey P. Gasch;
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中图分类细胞生物学;
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1. Defining flexible vs. inherent promoter architectures: the importance of dynamics and environmental considerations. [J] . Huebert D.J., Gasch A.P. Nucleus . 2012,第5期

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3. Regulation of virulence in Brucella: An eclectic repertoire of transcription factors defines the complex architecture of the virB promoter [J] . SieiraR. Future microbiology . 2013,第9期

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6. Defining flexible vs. inherent promoter architectures [O] . Dana J. Huebert, Audrey P. Gasch 2012

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Defining flexible vs. inherent promoter architectures

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