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Regulation and coordination of nuclear envelope and nuclear pore complex assembly

机译:核膜和核孔复合体组装的调控与协调

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In metazoans with “open” mitosis, cells undergo structural changes involving the complete disassembly of the nuclear envelope (NE). In post-mitosis, the dividing cell faces the difficulty to reassemble NE structures in a highly regulated fashion around separated chromosomes. The de novo formation of nuclear pore complexes (NPCs), which are gateways between the cytoplasm and nucleoplasm across the nuclear membrane, is an archetype of macromolecular assembly and is therefore of special interest. The reformation of a functional NE further involves the reassembly and organization of other NE components, the nuclear membrane and NE proteins, around chromosomes in late mitosis. ? Here, we discuss the function of NE components, such as lamins and INM proteins, in NE reformation and highlight recent results on coordination of NPC and NE assembly.
机译:在具有“开放”有丝分裂的后生动物中,细胞发生结构性变化,涉及核被膜(NE)的完全分解。在有丝分裂后,分裂细胞面临着在分离的染色体周围以高度调控的方式重组NE结构的困难。从头形成的核孔复合物(NPC)是大分子组装的原型,是跨细胞膜的细胞质和核质之间的通道,因此受到特别关注。功能性NE的重整还涉及晚期有丝分裂中染色体周围的其他NE成分,核膜和NE蛋白的重组和组织。 ?在这里,我们讨论了NE成分(如lamins和INM蛋白)在NE重构中的功能,并着重介绍了NPC和NE装配的协调方面的最新成果。

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