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When yeast cells meet, karyogamy!

机译：当酵母细胞相遇时，核型！

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摘要

Cytoskeleton-mediated transport processes are central to the subcellular organization of cells. The nucleus constitutes the largest organelle of a cell, and studying how it is positioned and moved around during various types of cell morphogenetic processes has puzzled researchers for a long time. Now, the molecular architectures of the underlying dynamic processes start to reveal their secrets. ? In yeast, karyogamy denotes the migration of two nuclei toward each other—termed nuclear congression—upon partner cell mating and the subsequent fusion of these nuclei to form a diploid nucleus. It constitutes a well-studied case. Recent insights completed the picture about the molecular processes involved and provided us with a comprehensive model amenable to quantitative computational simulation of the process. This review discusses our understanding of yeast nuclear congression and karyogamy and seeks to explain how a detailed, quantitative and systemic understanding has emerged from this knowledge.
机译：细胞骨架介导的转运过程是细胞亚细胞组织的核心。细胞核构成细胞的最大细胞器，研究细胞在各种类型的细胞形态发生过程中如何定位和运动一直困扰着研究人员很长时间。现在，潜在的动态过程的分子体系结构开始揭示它们的秘密。 ？在酵母中，核配体是指两个细胞核在伴侣细胞交配时彼此迁移（称为核大会），随后这些细胞核融合形成二倍体细胞核。这是一个经过充分研究的案例。最近的见解完成了有关所涉及的分子过程的图景，并为我们提供了适合该过程的定量计算模拟的综合模型。这篇综述讨论了我们对酵母核大会和核分裂症的理解，并试图解释如何从这种知识中形成详细，定量和系统的理解。

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