Toward understanding the structure of the vertebrate nuclear pore complex

Martin Beck; Joseph S Glavy

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Toward understanding the structure of the vertebrate nuclear pore complex

机译：理解脊椎动物核孔复合体的结构

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Nuclear pore complexes are large macromolecular assemblies that facilitate the nucleocytoplasmic exchange of macromolecules. Because of their intricate composition, membrane association, and sheer size, the integration of various, complementary structure determination approaches is a prerequisite for elucidating their structure. We have recently employed such an integrated strategy to analyze the scaffold structure of the cytoplasmic and nuclear rings of the human nuclear pore complex. In this extra view, we highlight two specific aspects of this work: the power of electron microscopy for bridging different resolution regimes and the importance of post-translational modifications for regulating nucleoporin interactions. We review recent technological developments and give a perspective toward future structure determination approaches.

机译：核孔复合物是大分子组装体，可促进大分子的核质交换。由于它们复杂的组成，膜结合和纯粹的大小，各种互补的结构确定方法的集成是阐明其结构的先决条件。我们最近采用了这种综合策略来分析人类核孔复合体的细胞质和核环的支架结构。在此额外的观点中，我们重点介绍了这项工作的两个具体方面：电子显微镜用于桥接不同分辨率机制的能力以及翻译后修饰对调节核孔蛋白相互作用的重要性。我们回顾了最新的技术发展，并对未来的结构确定方法给出了展望。

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《Nucleus》 |2014年第2期|共5页
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Martin Beck; Joseph S Glavy;
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中图分类细胞生物学;
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1. Toward understanding the structure of the vertebrate nuclear pore complex [J] . Martin Beck, Joseph S Glavy Nucleus . 2014,第2期

机译：试图了解脊椎动物核孔复合体的结构
2. B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis B-type nuclear lamin and the nuclear pore complex Nup107-160 influences maintenance of the spindle envelope required for cytokinesis in Drosophila male meiosis [J] . Yoshihiro H. Inoue, Hiroka Katsube, Karin Tanabe, Biology Open . 2016,第8期

机译：B型核纤层蛋白和核孔复合物Nup107-160影响维持果蝇雄性减数分裂所需的纺锤体包膜B型核纤溶蛋白和核孔复合物Nup107-160影响维持果蝇进行胞质分裂所需的纺锤体包膜雄性减数分裂B型核层蛋白和核孔复合体Nup107-160影响果蝇雄性减数分裂胞质分裂所需的纺锤体包膜的维持
3. Removal of a single pore subcomplex results in vertebrate nuclei devoid of nuclear pores. [J] . Harel A, Orjalo AV, Vincent T, Molecular cell . 2003,第4期

机译：去除单个孔亚复合物导致没有核孔的脊椎动物核。
4. PORE-SCALE NUMERICAL MODELING OF NUCLEAR MAGNETIC RESONANCE RESPONSE IN ROCKS WITH COMPLEX PORE STRUCTURE USING FINITE VOLUME METHOD [C] . Saurabh Tandon, Zoya Heidari, Grigorios Matenoglou SPWLA annual logging symposium;Society of Petrophysicists and Well Log Analysts, inc . 2017

机译：复杂体积结构岩石中核磁共振响应的大尺度数值模拟的有限体积法
5. A molecular characterization of the role of the vertebrate nucleoporin nup155 in nuclear protein import, export, mrna export, and nuclear pore assembly. [D] . Martell, Steven Walter. 2014

机译：脊椎动物核孔蛋白nup155在核蛋白导入，导出，mRNA导出和核孔装配中的作用的分子表征。
6. Toward understanding the structure of the vertebrate nuclear pore complex [O] . Martin Beck, Joseph S Glavy 2014

机译：试图了解脊椎动物核孔复合体的结构
7. Toward understanding the structure of the vertebrate nuclear pore complex [O] . Martin Beck, Joseph S Glavy 2014

机译：了解脊椎动物核孔隙络合物的结构

Toward understanding the structure of the vertebrate nuclear pore complex

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