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首页> 外文期刊>Nucleus >Do lamin B1 and lamin B2 have redundant functions?
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Do lamin B1 and lamin B2 have redundant functions?

机译：lamin B1和lamin B2是否具有冗余功能？

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Lamins B1 and B2 have a high degree of sequence similarity and are widely expressed from the earliest stages of development. Studies of Lmnb1 and Lmnb2 knockout mice revealed that both of the B-type lamins are crucial for neuronal migration in the developing brain. These observations naturally posed the question of whether the two B-type lamins might play redundant functions in the development of the brain. To explore that issue, Lee and coworkers generated “reciprocal knock-in mice” (knock-in mice that produce lamin B1 from the Lmnb2 locus and knock-in mice that produce lamin B2 from the Lmnb1 locus). Both lines of knock-in mice manifested neurodevelopmental abnormalities similar to those in conventional knockout mice, indicating that lamins B1 and B2 have unique functions and that increased production of one B-type lamin cannot compensate for the loss of the other.
机译：核纤层蛋白B1和B2具有高度的序列相似性，并从发展的最早阶段就被广泛表达。对Lmnb1和Lmnb2基因敲除小鼠的研究表明，两种B型lamin对发育中的大脑神经元迁移至关重要。这些观察结果自然地提出了两个B型lamin是否在大脑发育中发挥多余功能的问题。为了探讨该问题，Lee和他的同事制作了“相互敲入小鼠”（从Lmnb2基因座产生Lamin B1的敲入小鼠和从Lmnb1基因座产生Lamin B2的敲入小鼠）。这两类敲入小鼠的神经发育异常均与常规敲除小鼠相似，表明lamins B1和B2具有独特的功能，一种B型核纤层蛋白产量的增加无法弥补另一种的损失。

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