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Nuclear positioning by actin cables and perinuclear actin

机译:肌动蛋白电缆和核周肌动蛋白的核定位

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Nuclear positioning is an important process during development and homeostasis. Depending on the affected tissue, mislocalized nuclei can alter cellular processes such as polarization, differentiation, or migration and lead ultimately to diseases. Many cells actively control the position of their nucleus using their cytoskeleton and motor proteins. We have recently shown that during Drosophila oogenesis, nurse cells employ cytoplasmic actin cables in association with perinuclear actin to position their nucleus. Here, we briefly summarize our work and discuss why nuclear positioning in nurse cells is specialized but the molecular mechanisms are likely to be more generally used.
机译:核定位是发育和体内平衡过程中的重要过程。根据受影响的组织,定位不正确的核会改变细胞过程,例如极化,分化或迁移,并最终导致疾病。许多细胞利用其细胞骨架和运动蛋白来主动控制其细胞核的位置。我们最近显示,在果蝇卵子发生过程中,护士细胞利用细胞质肌动蛋白电缆与核周肌动蛋白结合来定位其核。在这里,我们简要总结了我们的工作,并讨论了为什么护士细胞中的核定位是专门的,但分子机制却可能会更普遍地使用。

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