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Nucleosomal organization and DNA base composition patterns

机译：核糖体组织和DNA碱基组成模式

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Nucleosomes are the basic units of chromatin. They compact the genome inside the nucleus and regulate the access of proteins to DNA. In the yeast genome, most nucleosomes occupy well-defined positions, which are maintained under many different physiological situations and genetic backgrounds. Although several short sequence elements have been described that favor or reduce the affinity between histones and DNA, the extent to which the DNA sequence affects nucleosome positioning in the genomic context remains unclear. Recent analyses indicate that the base composition pattern of mononucleosomal DNA differs among species, and that the same sequence elements have a different impact on nucleosome positioning in different genomes despite the high level of phylogenetic conservation of histones. These studies have also shown that the DNA sequence contributes to nucleosome positioning to the point that it is possible to design synthetic DNA molecules capable of generating regular and species-specific nucleosomal patterns in vivo .
机译：核小体是染色质的基本单位。它们压紧细胞核内的基因组并调节蛋白质与DNA的接触。在酵母基因组中，大多数核小体占据明确的位置，这些位置在许多不同的生理情况和遗传背景下得以维持。尽管已经描述了一些短序列元件，其有利于或降低组蛋白与DNA之间的亲和力，但是尚不清楚DNA序列影响基因组环境中核小体定位的程度。最近的分析表明，单核苷酸DNA的碱基组成模式在物种之间有所不同，尽管组蛋白的系统进化保守性很高，但相同的序列元件对不同基因组中核小体的定位有不同的影响。这些研究还表明，DNA序列有助于核小体定位，以至于有可能设计能够在体内产生规则的和物种特异性的核小体模式的合成DNA分子。

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