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n-3 polyunsaturated fatty acids supplementation in psoriasis: a review

机译：牛皮癣中n-3多不饱和脂肪酸的补充

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Psoriasis is an immune mediated chronic inflammatory disease of unknown etiology and characterized by epidermal hyperplasia and inappropriate immune activation, which affects the skin and joints as well.The immunopathogenesis of psoriasis involves changes in the innate and acquired (T lymphocytes) immune system. The cells of the innate immune system when activated produce growth factors, cytokines, and chemokines that act on cells of the acquired immune system and vice versa, being characterized as atype 1 immune response disease. Fish oil n-3 polyunsaturated fatty acids, mainly eicosapentaenoic (EPA), and docosahexaenoic acids (DHA), reduce symptoms in many inflammatory skin diseases. The mechanism of action of fish oil in the treatment of psoriasis is widely based on the alteration of epidermal and blood cell membrane lipid composition. In the present study, we performed a review of the several studies, which analyzed the action of n-3 polyunsaturated fatty acids in patients with psoriasis. Taken together, the majority of the studies showed that n-3 polyunsaturated fatty acids, mainly from marine origin, have beneficial effects and can be utilized as adjuvant therapy in psoriasis treatment. Both oral and intravenous administration of fish oil n-3 polyunsaturated fatty acids had positive effects. However, further studies are warranted to answer many intriguing questions, for instance, the ideal quantity of fish oil to be utilized, the effect on different forms and severity of psoriasis and last, but not least, the consequences of using fish oil n-3 polyunsaturated fatty acids on the cardiovascular features of patients with psoriasis.
机译：牛皮癣是一种病因不明的免疫介导的慢性炎症性疾病，其特征是表皮增生和不适当的免疫活化，也影响皮肤和关节。牛皮癣的免疫发病机制涉及先天和后天（T淋巴细胞）免疫系统的变化。先天性免疫系统的细胞在激活后会产生生长因子，细胞因子和趋化因子，这些因子作用于获得性免疫系统的细胞，反之亦然，被表征为1型免疫应答疾病。鱼油n-3多不饱和脂肪酸，主要是二十碳五烯酸（EPA）和二十二碳六烯酸（DHA），可减轻许多炎症性皮肤病的症状。鱼油治疗牛皮癣的作用机理广泛地基于表皮和血细胞膜脂质组成的改变。在本研究中，我们对几项研究进行了综述，这些研究分析了n-3多不饱和脂肪酸在牛皮癣患者中的作用。总体而言，大多数研究表明，主要来自海洋的n-3多不饱和脂肪酸具有有益的作用，可以用作牛皮癣治疗的辅助疗法。鱼油n-3多不饱和脂肪酸的口服和静脉给药均具有积极作用。但是，有必要进行进一步的研究来回答许多有趣的问题，例如，要使用的鱼油的理想量，对牛皮癣不同形式和严重程度的影响以及最后但并非最不重要的是使用鱼油n-3的后果多不饱和脂肪酸对牛皮癣患者心血管功能的影响。

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