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Polymorphisms in PPARG and APOE: relationships with lipid profile of adolescents with cardiovascular risk factors

机译：PPARG和APOE中的多态性：与青少年心血管疾病危险因素与脂质分布的关系

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BackgroundCardiovascular diseases constitute the main death cause worldwide resulting from a combination of genetic and lifestyle factors, and the prevalence among younger individuals has increased. It is important to early identify changes in lipid profile and the influence of genetic variations in specific genes on the individual patterns of lipid profile. Thus, the aim of this study was to verify the relationship of polymorphisms in PPAR-gamma gene ( PPARG ? rs1801282 ? Pro12Ala) and in apolipoprotein E gene ( APOE ? rs429358 + rs7412, determinants of the APOE2, APOE3, or APOE4 genotypes) with lipid profile of adolescents under cardiovascular risk factors. MethodsThis was a cross-sectional study with 115 adolescents aged 10–19?years, which presented cardiovascular risk factors. The students were evaluated regarding socioeconomic, anthropometric, biochemical, genetic, and dietetic variables. Student’s t test or Mann-Whitney test were applied to the analysis of the genotypes. Multiple linear regression analysis was performed to determine the variables that most influenced the lipid profile. ResultsAdolescents carrying PPARG Ala allele showed higher serum triglycerides ( p =?0.0423) and very low-density lipoprotein ( p =?0.0410) levels when compared to those carrying the wild genotype. For the APOE polymorphism, it was observed a trend of higher triglycerides ( p =?0.0712) and very low-density lipoprotein ( p =?0.0758) levels in the adolescents carrying the E4 allele when compared to those who did not carry this allele. ConclusionThe polymorphisms PPARG rs1801282 and APOE rs429358 + rs7412 seem to be related to the development of lipid profile alterations in adolescents.
机译：背景技术心血管疾病是遗传和生活方式因素共同导致的全球主要死亡原因，并且年轻人中的患病率有所增加。重要的是尽早识别脂质分布的变化以及特定基因的遗传变异对脂质分布的各个模式的影响。因此，本研究的目的是验证PPAR-γ基因（PPARG？rs1801282？Pro12Ala）和载脂蛋白E基因（APOE？rs429358 + rs7412，APOE2，APOE3或APOE4基因型的决定因素）多态性与心血管危险因素下青少年的血脂状况。方法这是一项横断面研究，研究对象为115位10-19岁的青少年，这些研究提出了心血管危险因素。对学生进行了社会经济，人体测量，生化，遗传和饮食变量方面的评估。将学生t检验或Mann-Whitney检验用于基因型分析。进行了多元线性回归分析，以确定对脂质谱影响最大的变量。结果携带PPARG Ala等位基因的青少年与携带野生基因型的青少年相比，血清甘油三酸酯（p =？0.0423）和极低密度脂蛋白（p =？0.0410）水平更高。对于APOE多态性，与未携带E4等位基因的青少年相比，观察到了青少年中甘油三酸酯含量较高（p =？0.0712）和极低密度脂蛋白（p =？0.0758）水平的趋势。结论PPARG rs1801282和APOE rs429358 + rs7412的多态性似乎与青少年脂质谱改变的发展有关。

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