...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nucleus >A lamin in lower eukaryotes?
【24h】

A lamin in lower eukaryotes?

机译：低等真核生物中的lamin？

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Lamins are the major components of the nuclear lamina and serve not only as a mechanical support, but are also involved in chromatin organization, epigenetic regulation, transcription and mitotic events. Despite these universal tasks, lamins have so far been found only in metazoans. Yet, recently we have identified Dictyostelium NE81 as the first lamin-like protein in a lower eukaryote. Based on the current knowledge, we draw a model for nuclear envelope organization in Dictyostelium in this Extra View and we review the experimental data that justified this classification. Furthermore we provide unpublished data underscoring the requirement of posttranslational CaaX-box processing for proper protein localization at the nuclear envelope. Sequence comparison of NE81 sequences from four Dictyostelia with bona fide lamins illustrates the evolutional relationship between these proteins. Under certain conditions these usually unicellular social amoebae congregate to form a multicellular body. We propose that the evolution of the lamin-like NE81 went along with the invention of multicellularity.
机译：核纤层蛋白是核纤层蛋白的主要成分，不仅用作机械支持，而且还参与染色质组织，表观遗传调控，转录和有丝分裂事件。尽管有这些通用的任务，但迄今为止仅在后生动物中发现了lamin。然而，最近我们已经确定了网柄菌属NE81是低等真核生物中的第一个层蛋白样蛋白。基于当前的知识，我们在此Extra View中绘制了盘基网状杆菌核膜结构的模型，并审查了证明该分类合理的实验数据。此外，我们提供了未发表的数据，这些数据强调了翻译后CaaX-box处理对于在核膜上正确定位蛋白质的要求。来自四个硬皮麦草与真正的lamin的NE81序列的序列比较说明了这些蛋白质之间的进化关系。在某些条件下，这些通常单细胞的社交变形虫聚集形成多细胞体。我们提出，类lamin样NE81的进化伴随着多细胞性的发明。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号