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Did the modulation of expression noise shape the evolution of three dimensional genome organizations in eukaryotes?

机译：表达噪声的调节是否影响了真核生物三维基因组组织的进化？

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The pervasive role of distant chromatin interactions in transcriptional regulation is increasingly becoming evident. There is a possibility that the greater diversity in chromatin interactions of a genomic locus could contribute to stochastic variation in its gene expression. However, this issue has not been addressed. Here, I present a few lines of evidence, which suggest that the variation in trans chromatin interactions might occur at the cost of expression noise. Genomic regions with nucleosome depletion, abundant and rapid transcription and with essential gene clusters exhibit relatively fewer trans chromatin interactions in the nucleus. Moreover, loci with greater number of interactions tend to show higher expression noise. Based on these observations, I hypothesize that the three dimensional organization of eukaryotic genomes might have evolved under a selective pressure to minimize the expression noise of essential gene clusters in the nucleus.
机译：远距离染色质相互作用在转录调控中的普遍作用越来越明显。基因组座位的染色质相互作用中更大的多样性可能会导致其基因表达的随机变化。但是，此问题尚未解决。在这里，我提供了一些证据，表明反式染色质相互作用的变化可能以表达噪音为代价。具有核小体耗竭，丰富且快速的转录并具有必需基因簇的基因组区域在细胞核中表现出相对较少的反式染色质相互作用。而且，具有更大数目的相互作用的基因座倾向于表现出更高的表达噪声。基于这些观察，我假设真核生物基因组的三维组织可能是在选择性压力下进化出来的，以最小化细胞核中必需基因簇的表达噪声。

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