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首页> 外文期刊>Nuclear Medicine Review >Equilibrium radionuclide ventriculography in the assessment of cardiotoxicity of chemotherapy and chemoradiotherapy in patients with breast cancer
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Equilibrium radionuclide ventriculography in the assessment of cardiotoxicity of chemotherapy and chemoradiotherapy in patients with breast cancer

机译：平衡放射性核素心室描记法评估乳腺癌化学疗法和放化疗的心脏毒性

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BACKGROUND: Multidrug chemotherapy increases the efficacyof the treatment, but at the same time rises its cardiotoxicity. Themajority of cardiac complications are caused by anthracyclines.Radiation therapy may intensify cardiotoxicity. The aim of thisstudy was to determine early changes of cardiac function usingradionuclide ventriculography in patients with breast cancer andto compare the toxicity of AC and AT chemotherapy programs. MATERIAL AND METHODS: The study included 71 patientswith breast cancer between the ages of 38 and 71 years. Allpatients after surgery were qualified for chemotherapy, and for37 (52%) of them subsequent irradiation treatment was planned.Patients received chemotherapy according to the scheme: AC— 47 patients (66%) and AT — 24 patients (34%). Patients wereirradiated using a photon beam (4 to 6 MeV) and an electronbeam (6–15 MeV). In all patients, before and six months afterthe treatment, radionuclide ventriculography was performed.RESULTS: In all 71 patients a reductions in left ventricularejection fraction (EF) and in peak filling rate (PFR) as well asan increase in the end-systolic and end-diastolic volumes (ESvol,EDvol) were observed. AC chemotherapy, where cumulativeanthracycline dose was higher, significantly decreased leftventricular ejection fraction and PFR and increased ESvol. AfterAT chemotherapy the EF reduction proved to be smaller. Radiotherapydid not significantly lower the value of EF as comparedto the group of patients who underwent chemotherapy. CONCLUSIONS: Radionuclide ventriculography is a usefulmethod of evaluating the cardiotoxicity of the treatment. Earlyindicators of myocardial damage are EF, PFR, ESvol and EDvol.AC chemotherapy, where the average cumulative dose of anthracyclineswas higher, caused more cardiotoxic effects thanAT chemotherapy.Applying additional radiotherapy did not significantly increasethe cardiotoxicity of the treatment.
机译：背景：多药化疗可提高治疗效果，但同时也会增加其心脏毒性。多数心脏并发症是由蒽环类药物引起的。放疗可能会增强心脏毒性。这项研究的目的是确定使用放射性核素心室造影术对乳腺癌患者心功能的早期变化，并比较AC和AT化疗方案的毒性。材料与方法：该研究纳入了71位年龄在38至71岁之间的乳腺癌患者。所有手术后的患者都符合化疗的条件，其中37例（52％）已计划进行放射治疗。患者按以下方案接受了化疗：AC- 47例（66％）和AT-24例（34％）。使用光子束（4至6 MeV）和电子束（6至15 MeV）对患者进行照射。结果：在所有患者中，治疗前和治疗后六个月进行了放射性核素心室描记。结果：在所有71名患者中，左室射血分数（EF）和峰值充盈率（PFR）均降低，并且收缩末期和末梢升高观察到舒张容积（ESvol，EDvol）。累积蒽环类药物剂量较高的AC化疗可显着降低左心室射血分数和PFR，并增加ESvol。 AT化疗后，EF减少被证实较小。与接受化疗的患者相比，放疗不会显着降低EF值。结论：放射性核素心室造影是评估治疗心脏毒性的一种有用方法。心肌损伤的早期指标是EF，PFR，ESvol和EDvol.AC化疗，蒽环类药物的平均累积剂量更高，其心脏毒性作用比AT化疗强。应用其他放疗并未显着增加治疗的心脏毒性。

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