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首页> 外文期刊>Nutrition Metabolism >The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor
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The common use of improper control diets in diet-induced metabolic disease research confounds data interpretation: the fiber factor

机译：在饮食引起的代谢性疾病研究中，控制饮食不当的普遍用法混淆了数据解释：纤维因子

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Diets used to induce metabolic disease are generally high in fat and refined carbohydrates and importantly, are usually made with refined, purified ingredients. However, researchers will often use a low fat grain-based (GB) diet containing unrefined ingredients as the control diet. Such a comparison between two completely different diet types makes it impossible to draw conclusions regarding the phenotypic differences driven by diet. While many compositional differences can account for this, one major difference that could have the greatest impact between GB and purified diets is the fiber content, both in terms of the level and composition. We will review recent data showing how fiber differences between GB diets and purified diets can significantly influence gut health and microbiota, which itself can affect metabolic disease development. Researchers need to consider the control diet carefully in order to make the best use of precious experimental resources.
机译：用于诱发代谢性疾病的饮食通常富含脂肪和精制碳水化合物，重要的是，通常使用精制提纯成分制成。但是，研究人员通常会使用含有未精制成分的低脂谷物基（GB）饮食作为对照饮食。两种完全不同的饮食类型之间的这种比较使得不可能就饮食驱动的表型差异得出结论。尽管许多成分差异可以解释这一点，但GB和纯化日粮之间可能产生最大影响的一个主要差异是纤维含量，无论是含量还是组成。我们将回顾最近的数据，这些数据表明GB日粮和纯日粮之间的纤维差异如何显着影响肠道健康和微生物群，而肠道菌群和微生物群本身又会影响代谢性疾病的发展。研究人员需要仔细考虑对照饮食，以充分利用宝贵的实验资源。

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