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首页> 外文期刊>Leukemia Research and Treatment >Cytotoxicity of Algae Extracts on Normal and Malignant Cells
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Cytotoxicity of Algae Extracts on Normal and Malignant Cells

机译：藻类提取物对正常和恶性细胞的细胞毒性

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Algae preparations are commonly used in alternative medicine. We examined the effects of algae extracts on normal hematopoietic cells and leukemia cells. Ethanol extracts were prepared ofDunaliella salina(Dun), Astaxanthin (Ast),Spirulina platensis(Spir), andAphanizomenon flos-aquae(AFA). Cell viability effects were completed by Annexin staining. Ast and AFA inhibited HL-60 and MV-4-11 whereas Dun and Spir had no effect. Primary AML blasts demonstrated increased apoptosis in AFA. Primary CLL cells showed apoptosis at 24 hours after exposure to Dun, Ast, Spir, and AFA. High AFA concentrations decreased viability of normal marrow cells. NormalCD34+viability was inhibited by Dun. Dun and AFA inhibited BFU-E, but all extracts inhibited CFU-GM. Cell-cycle analysis of AML cell lines showed G0/G1 arrest in the presence of AFA. These data suggest that algae extracts may inhibit AML cell lines and leukemia blasts, but they may also have potential inhibitory effects on normal hematopoiesis.
机译：藻类制剂常用于替代医学。我们检查了藻类提取物对正常造血细胞和白血病细胞的影响。制备了杜氏盐藻（Dunaliella salina），虾青素（Ast），钝顶螺旋藻（Spirulina platensis）（Spir）和Aphanizomenon flos-aquae（AFA）的乙醇提取物。通过膜联蛋白染色完成细胞活力效应。 Ast和AFA抑制HL-60和MV-4-11，而Dun和Spir没有作用。原发性AML原始细胞显示出AFA细胞凋亡增加。暴露于Dun，Ast，Spir和AFA后24小时，原代CLL细胞显示凋亡。高AFA浓度会降低正常骨髓细胞的活力。 Dun抑制了正常的CD34 +生存能力。 Dun和AFA抑制BFU-E，但所有提取物均抑制CFU-GM。 AML细胞系的细胞周期分析显示，存在AFA时G0 / G1停滞。这些数据表明藻类提取物可能抑制AML细胞系和白血病母细胞，但它们也可能对正常的造血作用具有潜在的抑制作用。

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