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首页> 外文期刊>Leukemia Research and Treatment >Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective
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Cotranscriptional Chromatin Remodeling by Small RNA Species: An HTLV-1 Perspective

机译：小RNA物种的共转录染色质重塑：HTLV-1的角度。

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Cell type specificity of human T cell leukemia virus 1 has been proposed as a possible reason for differential viral outcome in primary target cells versus secondary. Through chromatin remodeling, the HTLV-1 transactivator protein Tax interacts with cellular factors at the chromosomally integrated viral promoter to activate downstream genes and control viral transcription. RNA interference is the host innate defense mechanism mediated by short RNA species (siRNA or miRNA) that regulate gene expression. There exists a close collaborative functioning of cellular transcription factors with miRNA in order to regulate the expression of a number of eukaryotic genes including those involved in suppression of cell growth, induction of apoptosis, as well as repressing viral replication and propagation. In addition, it has been suggested that retroviral latency is influenced by chromatin alterations brought about by miRNA. Since Tax requires the assembly of transcriptional cofactors to carry out viral gene expression, there might be a close association between miRNA influencing chromatin alterations and Tax-mediated LTR activation. Herein we explore the possible interplay between HTLV-1 infection and miRNA pathways resulting in chromatin reorganization as one of the mechanisms determining HTLV-1 cell specificity and viral fate in different cell types.
机译：已经提出人T细胞白血病病毒1的细胞类型特异性是原代靶细胞与次要靶细胞中病毒结果差异的可能原因。通过染色质重塑，HTLV-1反式激活蛋白Tax在染色体整合的病毒启动子上与细胞因子相互作用，以激活下游基因并控制病毒转录。 RNA干扰是由调节基因表达的短RNA种类（siRNA或miRNA）介导的宿主固有防御机制。细胞转录因子与miRNA具有紧密的协同功能，以调节许多真核基因的表达，包括那些与抑制细胞生长，诱导细胞凋亡以及抑制病毒复制和繁殖有关的基因。另外，已经提出逆转录病毒潜伏期受miRNA引起的染色质改变的影响。由于Tax需要组装转录辅因子来进行病毒基因表达，因此影响染色质改变的miRNA与Tax介导的LTR激活之间可能存在紧密的联系。本文中，我们探讨了HTLV-1感染与miRNA途径之间可能的相互作用，导致染色质重组，这是确定不同细胞类型中HTLV-1细胞特异性和病毒命运的机制之一。

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