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首页> 外文期刊>FEBS Open Bio >Genome‐wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever
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Genome‐wide profiling of mRNA and lncRNA expression in dengue fever and dengue hemorrhagic fever

机译：登革热和登革出血热的mRNA和lncRNA表达的全基因组分析

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Dengue fever (DF) and dengue hemorrhagic fever (DHF) are recurrent diseases that are widespread in the tropics. Here, we identified candidate genes associated with these diseases by performing integrated analyses of DF ( GSE51808 ) and DHF ( GSE18090 ) microarray datasets in the Gene Expression Omnibus (GEO). In all, we identified 7635 differentially expressed genes (DEGs) in DF and 8147 DEGs in DHF as compared to healthy controls ( P ?0.05). In addition, we discovered 215 differentially expressed long non‐coding RNAs (DElncRNAs) in DF and 225 DElncRNAs in DHF. There were 1256 common DEGs and eight common DElncRNAs in DHF vs DF, DHF vs normal control, and DF vs normal control groups. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis revealed that signal transduction (false discovery rate?=?8.33E‐10), ‘toxoplasmosis’, and ‘protein processing in endoplasmic reticulum’ were significantly enriched pathways for common DEGs. We conclude that the MAGED1 , STAT1 , and IL12A genes may play crucial roles in DF and DHF, and suggest that our findings may facilitate the identification of biomarkers and the development of new drug design strategies for DF and DHF treatment.
机译：登革热（DF）和登革出血热（DHF）是热带地区常见的复发性疾病。在这里，我们通过对基因表达综合（GEO）中的DF（GSE51808）和DHF（GSE18090）微阵列数据集进行综合分析，确定了与这些疾病相关的候选基因。总之，与健康对照相比，我们在DF中鉴定了7635个差异表达基因（DEG），在DHF中鉴定了8147个DEG（P <？0.05）。此外，我们在DF中发现了215个差异表达的长非编码RNA（DElncRNA），在DHF中发现了225个DElncRNA。在DHF与DF，DHF与正常对照组以及DF与正常对照组中，共有1256个普通DEG和8个普通DElncRNA。基因本体论（GO）和《京都基因与基因组百科全书》（KEGG）富集分析表明，信号转导（错误发现率=？8.33E-10），“弓形体病”和“内质网中的蛋白质加工”是显着富集的途径用于常见的DEG。我们得出结论，MAGED1，STAT1和IL12A基因可能在DF和DHF中起关键作用，并表明我们的发现可能有助于生物标志物的鉴定以及DF和DHF治疗的新药物设计策略的发展。

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