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首页> 外文期刊>FEBS Open Bio >Eukaryotic translation initiation factor 3 subunit D overexpression is associated with the occurrence and development of ovarian cancer
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Eukaryotic translation initiation factor 3 subunit D overexpression is associated with the occurrence and development of ovarian cancer

机译：真核翻译起始因子3亚基D的过度表达与卵巢癌的发生发展有关

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Ovarian cancer is the most common cause of gynaecological cancer‐associated death; thus, promising biomarkers and new therapeutic targets for ovarian cancer must be explored. Here, we report that eukaryotic translation initiation factor 3 subunit D (EIF3D), a member of the EIF3 family, was overexpressed in ovarian cancer clinical tissues. Furthermore, the expression of EIF3D was correlated with the International Federation of Gynecology and Obstetrics stage and pathological differentiation stage. 3‐(4,5‐dimethylthylthiazol‐2‐yl)‐2 (MTT) and colony formation assays revealed that the lentivirus‐mediated knockdown of EIF3D suppresses cell proliferation in the ovarian tumour cell lines CAOV‐3 and SKOV‐3. Flow cytometry revealed that cells were arrested at the G2/M phase of the cell cycle and that cyclin‐dependent kinase 1 was also altered after EIF3D silencing. The results presented here demonstrate that EIF3D may play an important role in the occurrence and development of ovarian cancer.
机译：卵巢癌是妇科癌症相关死亡的最常见原因。因此，必须探索有希望的卵巢癌生物标志物和新的治疗靶标。在这里，我们报告说，EIF3家族成员的真核翻译起始因子3亚基D（EIF3D）在卵巢癌临床组织中过表达。此外，EIF3D的表达与国际妇产科联合会阶段和病理分化阶段相关。 3-（4,5-二甲基甲状腺噻唑-2-基）-2（MTT）和集落形成分析表明，慢病毒介导的EIF3D敲低可抑制卵巢癌细胞系CAOV-3和SKOV-3中的细胞增殖。流式细胞仪显示，细胞被阻滞在细胞周期的G2 / M期，EIF3D沉默后细胞周期蛋白依赖性激酶1也发生了改变。此处显示的结果表明EIF3D可能在卵巢癌的发生和发展中起重要作用。

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