HIV-1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination

Li-Jung Ko; Fu-Hsien Yu; Kuo-Jung Huang; Chin-Tien Wang

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HIV-1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination

机译：HIV-1基质结构域的去除改善了核衣壳正电荷消除所引起的病毒装配和加工缺陷

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Human immunodeficiency virus type 1 nucleocapsid (NC) basic residues presumably contribute to virus assembly via RNA, which serves as a scaffold for Gag-Gag interaction during particle assembly. To determine whether NC basic residues play a role in Gag cleavage (thereby impacting virus assembly), Gag processing efficiency and virus particle production were analyzed for an HIV-1 mutant NC15A, with alanine serving as a substitute for all NC basic residues. Results indicate that NC15A significantly impaired virus maturation in addition to significantly affecting Gag membrane binding and assembly. Interestingly, removal of the matrix (MA) central globular domain ameliorated the NC15A assembly and processing defects, likely through enhancement of Gag multimerization and membrane binding capacities.

机译：人类免疫缺陷病毒1型核衣壳（NC）基本残基可能通过RNA参与了病毒组装，RNA在颗粒组装过程中充当了Gag-Gag相互作用的支架。为了确定NC基本残基是否在Gag裂解中起作用（从而影响病毒装配），分析了HIV-1突变型NC15A的Gag加工效率和病毒颗粒产生，其中丙氨酸替代了所有NC基本残基。结果表明，NC15A除了显着影响Gag膜的结合和组装外，还大大损害了病毒的成熟度。有趣的是，去除基质（MA）中心球状结构域可以改善NC15A组装和加工缺陷，这可能是通过增强Gag多聚化和膜结合能力来实现的。

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《FEBS Open Bio》 |2015年第7期|共9页
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Li-Jung Ko; Fu-Hsien Yu; Kuo-Jung Huang; Chin-Tien Wang;
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中图分类生物化学;
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1. HIV-1 matrix protein repositioning in nucleocapsid region fails to confer virus-like particle assembly. [J] . Chang CY, Chang YF, Wang SM, Virology . 2008,第1期

机译：HIV-1基质蛋白在核衣壳区域中的重新定位无法赋予病毒样颗粒装配体。
2. Deletion of a Cys-His motif from the Alpharetrovirus nucleocapsid domain reveals late domain mutant-like budding defects [J] . Lee Eun-Gyung, Linial Maxine L. Virology . 2006,第1期

机译：从Alpharetrovirus核衣壳结构域中删除一个Cys-His基序揭示后期结构域突变体样芽出缺陷。
3. Deletion of a Cys-His motif from the Alpharetrovirus nucleocapsid domain reveals late domain mutant-like budding defects. [J] . Lee EG, Linial ML Virology . 2006,第1期

机译：从Alpharetrovirus核衣壳结构域中删除Cys-His基序揭示了后期结构域突变体样的出芽缺陷。
4. Efficient Numerical Integration for Post-processing and Matrix Assembly of Finite Element Subdomains [C] . Ryan Galagusz, Steve McFee International Conference on the Computation of Electromagnetic Fields . 2014

机译：有限元子域后处理和矩阵组装的有效数值积分
5. HIV-1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination [O] . Li-Jung Ko, Fu-Hsien Yu, Kuo-Jung Huang, -1

机译：去除HIV-1基质域可改善病毒衣壳的组装和加工缺陷这些缺陷是由于核衣壳电荷消除而引起的
6. HIV-1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination [O] . Ko Li-Jung, Yu Fu-Hsien, Huang Kuo-Jung, 2015

机译：HIV-1基质结构域的去除改善了核衣壳正电荷消除引起的病毒装配和加工缺陷

HIV-1 matrix domain removal ameliorates virus assembly and processing defects incurred by positive nucleocapsid charge elimination

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