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首页> 外文期刊>FEBS Open Bio >Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis
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Association between Apolipoprotein E polymorphism and myocardial infarction risk: A systematic review and meta-analysis

机译：载脂蛋白E基因多态性与心肌梗死风险之间的关联：系统评价和荟萃分析

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Published data regarding the association between Apolipoprotein E (ApoE) genetic variation and myocardial infarction (MI) risk were not always consistent. Therefore, the current meta-analysis was conducted to derive a more precise estimation of the association between ApoE polymorphism and MI risk. PubMed and Web of Science were searched to identify relevant studies. Summary odds ratio (ORs) and 95% confidence intervals (CIs) were calculated using random-effect or fixed-effect models based on the heterogeneity of included studies. All the tests were performed using Stata 11.0. A total of 22 eligible studies were identified in this meta-analysis. The results show that ApoE @e2 and @e4 alleles were associated with MI risk. The study suggests that there is close association between ApoE polymorphism and MI risk. It shows that ApoE @e2 allele is a protective factor of MI, while @e4 allele is a risk factor of MI, especially in Caucasian and Asian population. Nevertheless, well-designed, unbiased and larger sample size studies are required to confirm the results.
机译：关于载脂蛋白E（ApoE）遗传变异与心肌梗塞（MI）风险之间关系的已发表数据并不总是一致的。因此，进行了当前的荟萃分析，以得出ApoE多态性与MI风险之间关联的更精确估计。搜索PubMed和Web of Science以确定相关研究。根据纳入研究的异质性，使用随机效应或固定效应模型计算总比值比（OR）和95％置信区间（CI）。所有测试均使用Stata 11.0进行。这项荟萃分析共鉴定出22项合格研究。结果表明，ApoE @ e2和@ e4等位基因与MI风险相关。研究表明，ApoE多态性与MI风险之间存在密切关联。结果表明，ApoE @ e2等位基因是MI的保护因子，而@ e4等位基因是MI的危险因子，尤其是在白种人和亚洲人群中。尽管如此，仍需要精心设计，公正和更大样本量的研究来确认结果。

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