The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine

Omar Al Ustwani; Jessica D. Greene; Meir Wetzler

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The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine

机译：5-阿扎胞苷治疗失败后骨髓增生异常综合征患者小剂量持久口服氯法拉滨的使用

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Patients with myelodysplastic syndrome who fail hypomethylating agents have a very short median survival and about 25% risk of disease transformation to acute myeloid leukemia. We report our experience with low-dose protracted oral clofarabine in one patient who achieved stable disease for more than two years after failing 5-azacitidine.

机译：失败者使用低甲基化药物的骨髓增生异常综合症患者的中位生存期非常短，疾病转化为急性髓性白血病的风险约为25％。我们报告了一名5-阿扎胞苷失败后病情稳定两年以上的患者接受小剂量持久口服氯法拉滨的经验。

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《Leukemia Research Reports》 |2013年第1期|共2页
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Omar Al Ustwani; Jessica D. Greene; Meir Wetzler;
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中图分类肿瘤学;
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1. Phase I trial of low-dose oral Clofarabine in myelodysplastic syndromes patients who have failed frontline therapy [J] . Rudrapatna Venkatesh K., Morley Kimberly, Boucher Kenneth M., Leukemia Research: A Forum for Studies on Leukemia and Normal Hemopoiesis . 2015,第8期

机译：一线治疗失败的骨髓增生异常综合症患者低剂量口服氯法拉滨的I期试验
2. A phase I/II study of oral clofarabine plus low-dose cytarabine in previously treated acute myeloid leukaemia and high-risk myelodysplastic syndrome patients at least 60years of age [J] . Buckley Sarah A., Mawad Raya, Gooley Ted A., British Journal of Haematology . 2015,第3期

机译：I / II期口服氯法拉滨联合小剂量阿糖胞苷治疗至少60岁之前接受过治疗的急性髓细胞白血病和高危骨髓增生异常综合征患者的I / II期研究
3. A randomized study of clofarabine versus clofarabine plus low-dose cytarabine as front-line therapy for patients aged 60 years and older with acute myeloid leukemia and high-risk myelodysplastic syndrome. [J] . Faderl S, Ravandi F, Huang X, Blood: The Journal of the American Society of Hematology . 2008,第5期

机译：氯法拉滨与氯法拉滨加小剂量阿糖胞苷作为一线治疗针对60岁及以上的急性髓细胞性白血病和高危骨髓增生异常综合症患者的一线治疗的随机研究。
4. Acquired Glanzmann Thrombasthenia in a Patient with Myelodysplastic Syndrome [C] . A. Trummer, A. Tiede, R. Eisert Hemophilia Symposium . 2008

机译：在患有髓细胞增强综合征的患者中获得了Glanzmann血栓血管瘤
5. Chronic Bone Marrow Failure and Transfusion Patterns: Epidemiological Studies of Blood Transfusions and Outcomes in Patients with Myelodysplastic Syndromes [D] . Rydén, Jenny. 2021

机译：慢性骨髓衰竭和输血模式：骨髓增生综合征患者出血和结果的流行病学研究
6. The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine [O] . Omar Al Ustwani, Jessica D. Greene, Meir Wetzler 2013

机译：5-阿扎胞苷治疗失败后骨髓增生异常综合征患者小剂量持久口服氯法拉滨的使用
7. The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine [O] . Al Ustwani Omar, Greene Jessica D., Wetzler Meir 2013

机译：5-阿扎胞苷治疗失败后骨髓增生异常综合征患者小剂量持久口服氯法拉滨的使用

The use of low-dose protracted oral clofarabine in a patient with myelodysplastic syndrome after failing 5-azacitidine

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