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首页> 外文期刊>FEBS Open Bio >Protection by Huang‐Lian‐Jie‐Du decoction and its constituent herbs of lipopolysaccharide‐induced acute kidney injury
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Protection by Huang‐Lian‐Jie‐Du decoction and its constituent herbs of lipopolysaccharide‐induced acute kidney injury

机译：黄连解毒汤及其成分对脂多糖所致急性肾损伤的保护作用

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摘要

Sepsis, characterized by systemic inflammation, often leads to end‐organ dysfunction, such as acute kidney injury (AKI). Despite of the severity and frequency of septic AKI in clinic, its pathogenesis is still poorly understood. Combined with histopathology evaluations, mortality assessments, biochemical evaluations, reverse transcription (RT) reaction and quantitative real‐time PCR, and western blot, 1H NMR‐based metabolomics approach was applied to investigate effects of Huang‐Lian‐Jie‐Du‐Decotion (HLJDD), a traditional Chinese medicine prescription, and its four component herbs on lipopolysaccharide (LPS)‐induced septic AKI and the underlying mechanism. LPS induced kidney dysfunction via activation of NF‐κB and mitogen‐activated protein kinases (MAPKs), by excessive production of IL‐6, tumor necrosis factor‐α, inducible nitric oxide synthase, and COX‐2, producing perturbance in energy metabolism and oxidative stress. HLJDD and its component herbs could effectively inhibit LPS‐induced AKI in mice by inhibiting NF‐κB and MAPK activation and activating the Akt/HO‐1 pathway, and by markedly ameliorating disturbances in oxidative stress and energy metabolism induced by LPS. The four‐component herbs could complement each other.
机译：以全身性炎症为特征的败血症通常会导致终末器官功能障碍，例如急性肾损伤（AKI）。尽管临床上脓毒症AKI的严重程度和发生频率，其发病机理仍知之甚少。结合组织病理学评估，死亡率评估，生化评估，逆转录（RT）反应和定量实时PCR以及Western blot，基于1H NMR的代谢组学方法被用于研究黄连杰杜克汤（ HLJDD），一种中药处方及其在脂多糖（LPS）诱导的化脓性AKI中的四成分草药及其潜在机理。 LPS通过过量产生IL-6，肿瘤坏死因子-α，诱导型一氧化氮合酶和COX-2导致NF-κB和丝裂原活化蛋白激酶（MAPK）活化，从而导致肾脏功能异常，从而在能量代谢和氧化应激。 HLJDD及其成分草药可以通过抑制NF-κB和MAPK激活并激活Akt / HO-1途径，并显着减轻LPS诱导的氧化应激和能量代谢障碍，从而有效抑制LPS诱导的小鼠AKI。四种成分的草药可以互相补充。

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