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首页> 外文期刊>Leprosy review >Non-adherence to steroid therapy in leprosy reaction and neuritis
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Non-adherence to steroid therapy in leprosy reaction and neuritis

机译：在麻风反应和神经炎中不坚持类固醇治疗

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Nerve Function Impairment has been a prime hallmark of Type 1 Reaction in leprosy, whichoften leads to deformities and disability if not treated effectively.1 Steroid has been a drug ofchoice to treat severe reactions and nerve damage since the mid-20th century. Therecommended therapy regimen starts with 40mg per day for 2 weeks, followed by subsequenttapering for 12 weeks.2 Although the optimal dose and duration of therapy are still beingstudied, steroid is generally accepted as the standard treatment. It is evident from publishedarticles that oral steroid therapy may reverse nerve function impairment up to 50 – 70%.3–5Therefore completing appropriate courses of steroid therapy may improve the function ofinvolved peripheral nerves, and prevent the development of secondary deformity. For manytherapeutic regimes in chronic disease like hansen’s and tuberculosis (Multi-drug therapy andWHO oral steroid therapy), poor adherence affects the clinical outcome and results in aconsiderable financial burden on society and modern health care system.4.
机译：神经功能障碍一直是麻风病1型反应的主要特征，如果不加以有效治疗，通常会导致畸形和残疾。1自20世纪中叶以来，类固醇一直是治疗严重反应和神经损伤的首选药物。建议的治疗方案从每天40mg开始治疗2周，然后逐渐减少治疗12周。2尽管仍在研究最佳治疗剂量和持续时间，但类固醇通常被认为是标准治疗方法。从已发表的文章中可以明显看出，口服类固醇激素疗法可以使多达50％至70％的神经功能受损逆转。3-5因此，完成适当的类固醇激素疗法可以改善周围神经的功能，并预防继发性畸形的发展。对于汉森氏菌和肺结核（多种药物疗法和世卫组织口服类固醇疗法）等慢性病的许多治疗方案，依从性差会影响临床结果，并给社会和现代医疗系统带来巨大的经济负担。4。

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