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首页> 外文期刊>Norsk Epidemiologi >Lungekreft blant norske nikkelverksarbeidere: Nytt lys p? en klassisk studie
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Lungekreft blant norske nikkelverksarbeidere: Nytt lys p? en klassisk studie

机译：挪威镍厂工人中的肺癌：新的亮点？经典研究

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SAMMENDRAGI 1973 ble det p?vist ?kt risiko for lunge- og nese-/bihulekreft blant norske nikkelverksarbeidere i en epidemiologiskunders?kelse fra Kreftregisteret. Analysene var basert p? 48 lungekrefttilfeller, og man fant atrisikoen var h?yest i den gruppen som hadde lengst ansettelse i roste-, smelte- og elektrolyseavdelingene.Tilsvarende funn var tidligere gjort blant nikkelarbeidere i andre land, og unders?kelsen vakte oppsikt fordiforh?yet risiko ogs? ble funnet blant ansatte i elektrolysen. Senere analyser med spesifikke eksponeringsdatahar vist at kreftfaren er n?rt knyttet til eksponering for vannl?selige nikkelformer. Nye data er n? blitt samletinn i forbindelse med en pasient-kontroll-unders?kelse basert p? 213 tilfeller av lungekreft og 525 kontrollpersoner.P? bakgrunn av opplysningene er relativ risiko regnet ut ved hjelp av regresjonsmodeller derf?lgende faktorer var inkludert: total varighet av ansettelse ved bedriften, eller varighet av ansettelse i ulikeavdelinger, tidspunkt for f?rsteansettelse og r?ykevaner. Resultatene fra pasient-kontroll-analysen bekreftetfunnene fra 1973 n?r disse ble regnet om til relativ risiko, og tydet p? at konklusjonene fra den gang varvalide selv om analysene var basert p? f?rre arbeidstakere, kortere observasjonstid, en forenklet inndelingav arbeidstakerene i henhold til deres avdelingshistorikk, og manglende opplysninger om r?ykevanene.Grimsrud TK.?Lung cancer among Norwegian nickel-refinery workers: Reappraisial ofa classical study.?Nor J Epidemiol 2001; 11 (2): 171-176. ENGLISH SUMMARYIn 1973, increased risk of cancer of the lung and nasal cavities was demonstrated among Norwegian nickelworkers in a study from The Cancer Registry of Norway (Kreftregisteret). The analyses were based on 48cases of lung cancer and the highest risk was found in workers with the longest employment in the electrolysis,roasting, and smelting departments. The study gave supportive evidence to epidemiological findingsfrom other countries and was the first to identify an elevated risk in electrolysis workers. Evaluations basedon specific exposure information have indicated a clear carcinogenic effect from water-soluble nickel compounds.New information has been collected for a case-control study including 213 cases of lung cancer and525 controls. Regression models were used to estimate the effect of the following variables: duration ofemployment at the refinery as a whole, or in three different department groups (electrolysis, roasting andsmelting, and maintenance), time of first employment at the refinery, and smoking. The results from thecase-control analyses were in agreement with most of the relative rates derived from the 1973 paper, andindicated that the conclusions in the oldest study were valid despite a much lower number of study subjects,a shorter follow-up, a simple categorisation of employees according to work history, and an absence of dataon smoking habits.
机译：总结1973年，挪威癌症登记处的一项流行病学研究表明，挪威镀镍工人中有患肺癌和鼻/鼻窦癌的风险。分析是基于？ 48例肺癌患者被发现是锈病，熔化和电解部门工作时间最长的人群中风险最高，以前在其他国家的镍业工人中也有类似的发现，该研究也因其风险增加而受到关注。在电解行业的员工中被发现。随后的具体接触数据分析表明，癌症风险与水溶性镍形式接触密切相关。现在有新数据？收集了与基于213例肺癌和525例对照。根据这些信息，使用回归模型计算相对风险，包括以下因素：公司的总工作时间，不同部门的工作时间，首次工作时间和吸烟习惯。患者对照分析的结果证实了1973年的发现，当时这些发现已转换为相对风险，并指出即使分析是基于那个时间的结论仍然有效？更少的员工，更短的观察时间，根据部门历史对员工进行简化的划分以及缺乏有关吸烟习惯的信息。 11（2）：171-176。摘要1973年，挪威癌症登记机构（Kreftregisteret）进行的一项研究表明，挪威的镍工作人员患肺癌和鼻腔癌的风险增加。该分析基于48例肺癌，在电解，焙烧和冶炼部门工作时间最长的工人中发现的风险最高。该研究为其他国家的流行病学调查结果提供了支持性证据，并且是首次发现电解工人风险升高的研究。根据具体的暴露信息进行的评估表明，水溶性镍化合物具有明显的致癌作用。已为一项病例对照研究（包括213例肺癌和525例对照）收集了新的信息。回归模型用于估计以下变量的影响：整个炼油厂或三个不同部门组（电解，焙烧，熔炼和维护）的雇佣时间，炼油厂的首次雇佣时间和吸烟。病例对照分析的结果与1973年论文得出的大多数相对比率一致，并表明尽管研究对象的数量少得多，随访时间短，分类简单，但最古老的研究结论仍然有效。员工的工作史，以及是否有吸烟习惯数据。

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