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首页> 外文期刊>Lipids in Health Disease >Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity
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Genetic and diet effects on Ppar-α and Ppar-γ signaling pathways in the Berlin Fat Mouse Inbred line with genetic predisposition for obesity

机译：遗传和饮食对具有肥胖遗传易感性的柏林肥胖小鼠自交系中Ppar-α和Ppar-γ信号通路的影响

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Background The Berlin Fat Mouse Inbred (BFMI) line is a new mouse model for obesity, which was long-term selected for high fatness. Peroxisome proliferator-activated receptors (PPARs) are involved in the control of energy homeostasis, nutrient metabolism and cell proliferation. Here, we studied the expression patterns of the different Ppar genes and the genes in the PPAR pathway in the BFMI line in comparison to physiological changes. Results At the age of 10 weeks, the BFMI mice exhibited marked obesity with enlarged adipocytes and high serum triglycerides concentrations in comparison to the often used mouse line C57BL/6 (B6). Between these two lines, gene expression analyses revealed differentially expressed genes belonging to the PPAR pathway, in particular genes of the lipogenesis and the fatty acid transport. Conclusion Surprisingly, the Ppar-α gene expression was up-regulated in liver and Ppar-γ gene expression was down-regulated in the white adipose tissue, indicating the activation of a mechanism that counteracts the rise of obesity.
机译：背景技术柏林肥胖小鼠近交系（BFMI）是针对肥胖症的一种新型小鼠模型，长期选择该模型是为了获得高脂肪。过氧化物酶体增殖物激活受体（PPAR）参与能量稳态，营养代谢和细胞增殖的控制。在这里，我们研究了不同的Ppar基因和BFMI系中PPAR途径中的基因与生理变化相比的表达模式。结果与通常使用的小鼠品系C57BL / 6（B6）相比，BFMI小鼠在10周龄时表现出明显的肥胖症，脂肪细胞增大，血清甘油三酯浓度升高。在这两条线之间，基因表达分析揭示了属于PPAR途径的差异表达基因，特别是脂肪生成和脂肪酸转运的基因。结论出乎意料的是，白色脂肪组织中Ppar-α基因的表达在肝脏中被上调，而Ppar-γ基因的表达在白色脂肪组织中被下调，这表明可以抑制肥胖的发生。

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