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首页> 外文期刊>Latin american journal of aquatic research >First approach of characterization of bioactive compound in Pyropia orbicularis during the daily tidal cycle
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First approach of characterization of bioactive compound in Pyropia orbicularis during the daily tidal cycle

机译：在每日潮汐周期中表征轮状拟南芥生物活性化合物的第一种方法

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ABSTRACT The red seaweed Pyropia orbicularis is an economic important species that occurs predominantly in the high intertidal zone along the chilean coast where it experiences extreme conditions under daily turning tides. Its gametophytic phase has been demonstrated to have a high desiccation tolerance, both at the genomic and proteomic levels, but studies at the metabolomic level are still lacking. This research aimed at characterizing compounds related to desiccation stress tolerance by performing several phase solid extractions with different solvents. Bioactivity-guided fractionation (antioxidant and antibacterial activities) was made for a more specific characterization. Compounds identification was done using LC-MS/MS. Results showed that P. orbicularis produces different compounds depending on the state of hydration during the tidal cycle. For example, minoxidil was only found under hydration, while vincamine only during desiccation. It was also found that the main antioxidant activity was most likely due to lutein and the antibacterial activity could be mainly attributed to compounds of lipid nature such as phosphatidylethanolamine (PE), phosphatidylserine (PS) and monogalactosyldiacylglycerol (MGDG). These results help to get a better understanding of the stress tolerance mechanisms in P. orbicularis and place it like a potential source of bioactive compounds.
机译：摘要红海紫苏热疫霉是一种重要的经济物种，主要发生在智利沿海高潮间带，在每天的海潮中会遇到极端条件。它的配子体阶段在基因组和蛋白质组学水平上都具有很高的脱水耐受性，但在代谢组学水平上仍然缺乏研究。这项研究旨在通过使用不同溶剂进行数次固相萃取来表征与脱水应力耐受性相关的化合物。进行了生物活性指导的分级分离（抗氧化和抗菌活性）以进行更具体的表征。使用LC-MS / MS进行化合物鉴定。结果表明，轮状疟原虫会根据潮汐周期中的水合状态产生不同的化合物。例如，米诺地尔仅在水合作用下被发现，而长春胺仅在干燥过程中被发现。还发现主要的抗氧化剂活性最可能归因于叶黄素，并且抗菌活性可能主要归因于脂质性质的化合物，例如磷脂酰乙醇胺（PE），磷脂酰丝氨酸（PS）和单半乳糖基二酰基甘油（MGDG）。这些结果有助于更好地了解轮虫假单胞菌的胁迫耐受机制，并将其定位为生物活性化合物的潜在来源。

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