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首页> 外文期刊>Lipids in Health Disease >Differential patterns of insulin secretion and sensitivity in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease versus patients with type 2 diabetes mellitus alone
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Differential patterns of insulin secretion and sensitivity in patients with type 2 diabetes mellitus and nonalcoholic fatty liver disease versus patients with type 2 diabetes mellitus alone

机译：2型糖尿病和非酒精性脂肪肝患者与单独2型糖尿病患者的胰岛素分泌和敏感性差异模式

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Background Nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM) often coexist and have adverse outcomes. The aim of our study was to elucidate metabolic abnormalities in patients with DM-NAFLD versus those with T2DM alone. Methods Patients were divided into two groups: 26 T2DM patients with NAFLD and 26 gender-, age-, and body mass index-matched patients with T2DM alone. Patients took a 75-g oral glucose tolerance test (OGTT), which measured serum insulin and C-peptide (C-p) levels at baseline (0 min), 30 min, 60 min, and 120 min after glucose challenge. Results Patients with DM-NAFLD or T2DM alone had similar blood glucose levels. β-cell hypersecretion was more obvious in patients with DM-NAFLD. In addition, fasting, early-phase, and late-phase C-peptide levels were significantly increased in patients with DM-NAFLD (ΔC-p 0–30 min, P?
机译：背景非酒精性脂肪肝疾病（NAFLD）和2型糖尿病（T2DM）通常并存并具有不良后果。我们研究的目的是阐明DM-NAFLD患者与单纯T2DM患者的代谢异常。方法将患者分为两组：26例患有NAFLD的T2DM患者和26例性别，年龄和体重指数匹配的T2DM患者。患者进行了75克口服葡萄糖耐量试验（OGTT），该试验在血糖激发后的基线时间（0分钟），30分钟，60分钟和120分钟测量了血清胰岛素和C肽（C-p）水平。结果单独使用DM-NAFLD或T2DM的患者血糖水平相似。 DM-NAFLD患者的β细胞分泌过多更为明显。此外，DM-NAFLD患者的空腹，早期和晚期C肽水平显着升高（ΔC-p0–30分钟，P 0.05;曲线下面积（AUC）Cp / PG 30-120分钟的比率，P 0.01;和AUC Cp 30-120分钟的比率，P 0.01）。在两组之间，OGTT期间的肝和肝外胰岛素抵抗无明显差异。 T2DM和NAFLD患者的肝胰岛素敏感性独立地导致OGTT的早期阶段（0–30分钟），而仅T2DM患者的30–120分钟的葡萄糖状态独立地导致晚期胰岛素分泌的显着不足。结论在胰岛素抵抗和高血糖水平相似的患者中，DM-NAFLD与单独的T2DM相比具有更高的血清胰岛素水平。高胰岛素血症主要由β细胞分泌过多引起。本研究证明了DM-NAFLD与单独的T2DM患者的胰岛素抵抗机制的病理生理差异。

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