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首页> 外文期刊>Lung India >Clinico-epidemiological features of the hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in Saurashtra region, India (September, 2009 to February, 2010)
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Clinico-epidemiological features of the hospitalized patients with 2009 pandemic influenza A (H1N1) virus infection in Saurashtra region, India (September, 2009 to February, 2010)

机译：印度索拉什特拉地区2009年甲型H1N1流感大流行住院患者的临床流行病学特征（2009年9月至2010年2月）

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Background:The first case of 2009 pandemic influenza A (H1N1) virus infection in India was reported in May, 2009 and in Saurashtra region in August, 2009. We describe the clinico-epidemiological characteristics of patients who were hospitalized with 2009 influenza A (H1N1) infection in Saurashtra region.Materials and Methods:From September, 2009 to February, 2010, we observed 274 persons infected with 2009 influenza A (H1N1) virus who were admitted in different hospitals in Rajkot city. Real-time reverse-transcriptase-polymerase-chain-reaction (RT-PCR) testing was used to confirm infection; the clinico-epidemiological features of the disease were closely monitored.Results:Of 274 patients, median age was 29.5 years, and 51.5% were males. Only 1.1% patients had recent travel history to infected region. Median time of five days was observed from onset of illness to influenza A (H1N1) diagnosis, while median time of six days reported for hospital stay. All admitted patients received oseltamivir drug, but only 16.1% received it within two days of onset of illness. One fourth of admitted patients were expired. The most common symptoms were cough (96.7%), fever (92%), sore throat and shortness of breathing, and coexisting conditions including diabetes mellitus (9.9%), hypertension (8.8%), chronic pulmonary diseases (5.5%) and pregnancy (5.5%) (P<0.05). Pneumonia was reported in 93% patients with chest radiography.Conclusion:We have demonstrated that infection-related illness affects both children and adults with survival of 74% patients. The median time from onset of illness to virus detection with use of real-time RT-PCR is five days. Pregnancy is found as a significant (P<0.05) risk factor for severe disease.
机译：背景：印度在2009年5月和2009年8月在索拉什特拉地区报告了2009年第一例大流行性A（H1N1）病毒感染。我们描述了2009年甲型H1N1（H1N1）住院患者的临床流行病学特征材料与方法：从2009年9月至2010年2月，我们观察到274名感染2009年甲型H1N1流感病毒的人在拉杰果德市的不同医院收治。实时逆转录聚合酶链反应（RT-PCR）测试用于确认感染。结果：274例患者中位年龄为29.5岁，其中男性占51.5％。只有1.1％的患者最近有去感染区域的旅行史。从发病到诊断出甲型流感（H1N1），平均时间为5天，而住院时间为6天。所有入院的患者均接受了奥司他韦药物，但只有16.1％的患者在发病后两天内接受了奥司他韦药物。四分之一的入院患者已过期。最常见的症状是咳嗽（96.7％），发烧（92％），喉咙痛和呼吸急促以及并存的疾病包括糖尿病（9.9％），高血压（8.8％），慢性肺部疾病（5.5％）和怀孕（5.5％）（P <0.05）。 93％的胸部X线片患者中报告有肺炎。结论：我们证明感染相关疾病会影响儿童和成人，其中74％的患者存活。从发病到使用实时RT-PCR进行病毒检测的中位时间为5天。发现妊娠是严重疾病的重要危险因素（P <0.05）。

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