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Clinical characteristics and treatment outcomes in 132 patients with malignant mesothelioma

机译：132例恶性间皮瘤的临床特征和治疗结果

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Purpose:Our objective is to scrutinize clinical, laboratory, radiological characteristics, treatment regimens, and treatment outcomes of malignant mesothelioma (MM) cases in our hospital.Materials and Methods:We investigated, retrospectively, the clinical characteristics and treatment outcomes of all 132 MM patients at Dicle University Hospital between January 2006 and April 2010.Results:A total of 82 (62.1%) patients were male, and 50 (37.9%) female. Median age was 56.0 years. Mean survival time was 9.6±6.9 months. Mean survival time of patients who had received best supportive care was 7.5 months, chemotherapy 10.4 months, and multimodality treatment regimen 12.6 months. Patients in the multimodality treatment group survived longer than did those in the other two groups (P=0.042). A total of 76 patients received chemotherapy, of whom 17 (22.3%) were administered Cisplatin/Carboplatin and Gemcitabine, 58 (76.4%) Cisplatin/Carboplatin and Pemetrexed, and one (1.3%) Cisplatin + Docetaxel. Complete and partial response to treatment in patients receiving Cisplatin/Carboplatin and Gemcitabine was found 47.1% and Cisplatin/Carboplatin and Pemetrexed was found 50.0% (P>0.05).Conclusions:MM related to asbestos exposure is seen frequently in Turkey. Patients present with the typical clinical features of dyspnea, weight loss, and chest pain. Survival analysis shows that patients receiving multimodality treatment may be better.
机译：目的：我们的目的是检查我院恶性间皮瘤（MM）的临床，实验室，放射学特征，治疗方案和治疗结果。材料与方法：我们回顾性调查了所有132 MM的临床特征和治疗结果结果：2006年1月至2010年4月在Dicle大学医院住院的患者中，男性82例（占62.1％），女性50例（占37.9％）。中位年龄是56.0岁。平均生存时间为9.6±6.9个月。接受最佳支持治疗的患者的平均生存时间为7.5个月，化疗为10.4个月，多模式治疗方案为12.6个月。多模式治疗组的患者生存时间长于其他两组（P = 0.042）。总共76例接受了化疗的患者，其中17例（22.3％）接受了顺铂/卡铂和吉西他滨，58例（76.4％）顺铂/卡铂和培美曲塞，以及一例（1.3％）顺铂+多西他赛。接受顺铂/卡铂和吉西他滨治疗的患者对治疗的完全和部分反应为47.1％，顺铂/卡铂和培美曲塞的患者为50.0％（P> 0.05）。结论：在土耳其，与石棉接触有关的MM很常见。患者表现出呼吸困难，体重减轻和胸痛的典型临床特征。生存分析表明，接受多模式治疗的患者可能更好。

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