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Effect of age on presentation with diabetes: Comparison of nondiabetic patients with new smear-positive pulmonary tuberculosis patients

机译：年龄对糖尿病表现的影响：非糖尿病患者与新涂片阳性肺结核患者的比较

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Background:Diabetes mellitus (DM) has been reported to modify the presenting features of pulmonary tuberculosis (PTB), but data regarding the effect of diabetes on the presentation of PTB are highly variable.Objective:To determine whether DM alters the demographic, clinical, and radiological manifestations of tuberculosis and whether the effect of diabetes varies with the age group of PTB patients.Materials and Methods :This prospective observational study was conducted on new smear-positive PTB patients with DM (PTB-DM group) and non-diabetic PTB patients (PTB group). Patients of both groups were again divided into six age groups (15–29, 30–39, 40–49, 50–59, 60–69, and >70 rears) to analyze and compare the impact of age on clinicoradiological presentations of PTB.Results:Patients in the PTB-DM group were significantly older (53.34 ± 14.06 year) in comparison to their nondiabetic counterparts (PTB group) (44.35 ± 18.14 year) (P < 0.001). The former group also had a lower male:female ratio, although the difference was not statistically significant (1.16:1 vs. 2.05:1, P = 0.101). Tuberculin positivity was significantly higher in the PTB group, compared with patients in the PTB-DM group (P < 0.004). The proportion of patients with lower lung field involvement (P = 0.003) and cavitations (P = 0.005) was also higher in the former group compared with the latter.Conclusion:Diabetic patients with tuberculosis were relatively older, had lower tuberculin positivity, and higher proportion of lower lung field involvement and cavitation in comparison to nondiabetic patients.
机译：背景：据报道，糖尿病（DM）可以改变肺结核（PTB）的表现特征，但有关糖尿病对PTB表现的影响的数据却存在很大差异。目的：确定DM是否会改变人口统计学，临床，材料和方法：该前瞻性观察性研究是针对新发涂阳的DM合并DM的PTB-DM组和非糖尿病性PTB的患者进行的前瞻性观察性研究患者（PTB组）。两组患者再次分为六个年龄组（15-29岁，30-39岁，40-49岁，50-59岁，60-69岁和> 70岁后方），以分析和比较年龄对PTB临床放射学表现的影响结果：与非糖尿病患者（PTB组）（44.35±18.14年）相比，PTB-DM组的患者明显更年长（53.34±14.06年）（P <0.001）。前一组的男性/女性比例也较低，尽管差异无统计学意义（1.16：1比2.05：1，P = 0.101）。与PTB-DM组患者相比，PTB组的结核菌素阳性率显着更高（P <0.004）。前者的肺野受累程度较低（P = 0.003）和空洞（P = 0.005）的比例也比后者高。结论：糖尿病合并肺结核的患者年龄较大，结核菌素阳性率较低，且较高与非糖尿病患者相比，下肺野受累和空化的比例。

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