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首页> 外文期刊>Lupus Science & Medicine >Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment
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Significantly reduced lymphadenopathy, salivary gland infiltrates and proteinuria in MRL-lpr/lpr mice treated with ultrasoluble curcumin/turmeric: increased survival with curcumin treatment

机译：用超溶性姜黄素/姜黄治疗的MRL-lpr / lpr小鼠可显着减少淋巴结病，唾液腺浸润和蛋白尿：姜黄素治疗可提高存活率

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Objectives Commercial curcumin (CU), derived from food spice turmeric (TU), has been widely studied as a potential therapeutic for a variety of oncological and inflammatory conditions. Lack of solubility/bioavailability has hindered curcumin's therapeutic efficacy in human diseases. We have solubilised curcumin in water applying heat/pressure, obtaining up to 35-fold increase in solubility (ultrasoluble curcumin (UsC)). We hypothesised that UsC or ultrasoluble turmeric (UsT) will ameliorate systemic lupus erythematosus (SLE) and Sj?gren's syndrome (SS)-like disease in MRL-lpr/lpr mice. Methods Eighteen female MRL-lpr/lpr (6 weeks old) and 18 female MRL-MpJ mice (6 weeks old) were used. Female MRL-lpr/lpr mice develop lupus-like disease at the 10th week and die at an average age of 17?weeks. MRL-MpJ mice develop lupus-like disease around 47?weeks and typically die at 73?weeks. Six mice of each strain received autoclaved water only (lpr-water or MpJ-water group), UsC (lpr-CU or MpJ-CU group) or UsT (lpr-TU or MpJ-TU group) in the water bottle. Results UsC or UsT ameliorates SLE in the MRL-lpr/lpr mice by significantly reducing lymphoproliferation, proteinuria, lesions (tail) and autoantibodies. lpr-CU group had a 20% survival advantage over lpr-water group. However, lpr-TU group lived an average of 16?days shorter than lpr-water group due to complications unrelated to lupus-like illness. CU/TU treatment inhibited lymphadenopathy significantly compared with lpr-water group (p=0.03 and p=0.02, respectively) by induction of apoptosis. Average lymph node weights were 2606±1147, 742±331 and 385±68?mg, respectively, for lpr-water, lpr-CU and lpr-TU mice. Transferase dUTP nick end labelling assay showed that lymphocytes in lymph nodes of lpr-CU and lpr-TU mice underwent apoptosis. Significantly reduced cellular infiltration of the salivary glands in the lpr-TU group compared with the lpr-water group, and a trend towards reduced kidney damage was observed in the lpr-CU and lpr-TU groups. Conclusions These studies show that UsC/UsT could prove useful as a therapeutic intervention in SLE/SS.
机译：目的商业姜黄素（CU）衍生自食品香料姜黄（TU），已被广泛研究为多种肿瘤和炎性疾病的潜在治疗剂。缺乏溶解度/生物利用度阻碍了姜黄素在人类疾病中的治疗功效。我们通过加热/加压将姜黄素溶解在水中，使溶解度（超可溶性姜黄素（UsC））增加了35倍。我们假设UsC或超溶性姜黄（UsT）将改善MRL-lpr / lpr小鼠的系统性红斑狼疮（SLE）和干燥综合征（SS）样疾病。方法使用18只雌性MRL-lpr / lpr（6周龄）和18只雌性MRL-MpJ小鼠（6周龄）。雌性MRL-lpr / lpr小鼠在第10周发展为狼疮样疾病，平均年龄为17周。 MRL-MpJ小鼠在47周左右发展为狼疮样疾病，通常在73周出现死亡。每个品系的六只小鼠在水瓶中仅接受高压灭菌水（lpr-水或MpJ-TU组），UsC（lpr-CU或MpJ-CU组）或UsT（lpr-TU或MpJ-TU组）。结果UsC或UsT通过显着减少淋巴增殖，蛋白尿，病变（尾部）和自身抗体来改善MRL-lpr / lpr小鼠的SLE。 lpr-CU组比lpr-water组具有20％的生存优势。然而，由于与狼疮样疾病无关的并发症，lpr-TU组的平均寿命比lpr-water组短16天。与lpr-water组相比，CU / TU处理通过诱导细胞凋亡显着抑制淋巴结病（分别为p = 0.03和p = 0.02）。 lpr-water，lpr-CU和lpr-TU小鼠的平均淋巴结重量分别为2606±1147、742±331和385±68？mg。转移酶dUTP缺口末端标记检测表明，lpr-CU和lpr-TU小鼠淋巴结中的淋巴细胞发生凋亡。与lpr-water组相比，lpr-TU组的唾液腺细胞浸润显着减少，并且在lpr-CU和lpr-TU组中观察到肾脏损害减少的趋势。结论这些研究表明，USC / UsT可以作为治疗SLE / SS的有用手段。

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