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首页> 外文期刊>Records of Natural Products >Phytochemical and Biological Evaluation of Ultrasound-Assisted Spray Dried Lonicera etrusca for Potential Management of Diabetes
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Phytochemical and Biological Evaluation of Ultrasound-Assisted Spray Dried Lonicera etrusca for Potential Management of Diabetes

机译：超声辅助喷雾干燥忍冬属植物对糖尿病的潜在控制作用的植物化学和生物学评估

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Honeysuckle or Lonicera etrusca is one of the important medicinal-plants that is traditionally-used as a potential antioxidant. The aim of this work was to make a phytochemical-evaluation of Lonicera etrusca ultrasound-assisted spray-dried extract versus conventional-method utilizing RP-HPLC aided-method in the potential management of diabetes. Ultrasound-assisted spray-drying (US-SD) is a new productive-technique aiming at increasing the efficiency and extract-yield in addition to short time of exposure to elevated temperature thus improving product stability. A bio-guided study utilizing RP-HPLC, 1H and 13C NMR methods indicated that the most active antidiabetic-compound was isochlorogenic acid (ICA). Diabetes measurement utilizing glucometers and HbA1c methods was applied. Serum-insulin levels and serum-catalase (CAT) was also monitored. The US-SD preserved time by 4 folds and with higher yield (ca. 20%) than the conventional method. The US-SD also had higher quality in US-SD honeysuckle (HS-sd) constituents than the conventional method as supported by RP-HPLC analysis. Rotary evaporated honeysuckle (HS-r) major peaks identified were; chlorogenic acid (38.6%), caffeic acid (5.8%), isochlorogenic acid (36.1%), luteolin-7-O-glucoside (3.3%), and quercetin (3.0%). HS-sd major peaks identified were; chlorogenic acid (40.5%), caffeic acid (6.4%), isochlorogenic acid (43.3%), luteolin-7-O-glucoside (3.5%), and quercetin (3.2%). HS-sd had significant (p?0.05, n=7/group) antidiabetic-activity more than HS-r. HS-sd had more-significant dose-dependent increase in serum-insulin, CAT-levels and body-weights more prominent than HS-r. Compared to conventional-methods, US-SD has shown to be time-conserving, efficient, and active-ingredients preserving method. The antidiabetic-potentials of HS-sd and ICA were probably mediated via the significant insulin-secretagogue effect and the attenuation glucose-provoked oxidative-stress.
机译：金银花或忍冬忍冬是重要的药用植物之一，传统上被用作潜在的抗氧化剂。这项工作的目的是对金银花超声辅助喷雾干燥提取物与常规方法进行植物化学评价，利用RP-HPLC辅助方法对糖尿病进行潜在治疗。超声辅助喷雾干燥（US-SD）是一种新的生产技术，旨在提高效率和提取物产量，此外还可以缩短暴露在高温下的时间，从而提高产品的稳定性。利用RP-HPLC，1H和13C NMR方法进行的生物指导研究表明，最有效的抗糖尿病化合物是异绿原酸（ICA）。应用了利用血糖仪和HbA1c方法进行的糖尿病测量。还监测血清胰岛素水平和血清过氧化氢酶（CAT）。与传统方法相比，US-SD可以将时间节省4倍，并且产率更高（约20％）。与RP-HPLC分析所支持的传统方法相比，US-SD的金银花（HS-sd）成分的质量也更高。鉴定出旋转蒸发的金银花（HS-r）主峰。绿原酸（38.6％），咖啡酸（5.8％），异绿原酸（36.1％），木犀草素-7-O-葡萄糖苷（3.3％）和槲皮素（3.0％）。鉴定出HS-sd主峰;绿原酸（40.5％），咖啡酸（6.4％），异绿原酸（43.3％），木犀草素-7-O-葡萄糖苷（3.5％）和槲皮素（3.2％）。 HS-sd的抗糖尿病活性显着高于HS-r（p <0.05，n = 7 /组）。 HS-sd的血清胰岛素，CAT水平和体重的剂量依赖性增加比HS-r更显着。与传统方法相比，US-SD已证明是一种节省时间，高效且有效的成分保存方法。 HS-sd和ICA的抗糖尿病潜力可能是通过显着的胰岛素分泌作用和葡萄糖诱发的氧化应激减弱来介导的。

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