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首页> 外文期刊>Redox Biology >Hydroxytyrosol supplementation increases vitamin C levels in vivo . A human volunteer trial
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Hydroxytyrosol supplementation increases vitamin C levels in vivo . A human volunteer trial

机译:补充羟基酪醇可增加体内的维生素C水平。志愿者试验

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Hydroxytyrosol (HT) is a main phenolic component of olive oil. In this study, we investigated the safety and effects produced by HT purified (99.5%) from olive mill waste. HT was administered at a daily dosage of 45 mg for 8 weeks to volunteers with mild hyperlipidemia (n=14). We measured markers of cardiovascular disease risk, enzyme markers of several clinical conditions, hematology, antioxidant parameters, vitamins and minerals at baseline (T0), 4 weeks (T4) and 8 weeks (T8). The values obtained at T4 and T8 were compared with baseline. We found that the HT dose administered was safe and mostly did not influence markers of cardiovascular disease, blood lipids, inflammatory markers, liver or kidney functions and the electrolyte balance. Serum iron levels remained constant but a significant (P
机译:羟基酪醇(HT)是橄榄油的主要酚类成分。在这项研究中,我们调查了从橄榄磨废料中经HT纯化(99.5%)所产生的安全性和效果。 HT以轻度高脂血症(n = 14)的志愿者每天以45 mg的剂量给药8周。我们在基线(T0),4周(T4)和8周(T8)时测量了心血管疾病风险的标志物,几种临床状况,血液学,抗氧化剂参数,维生素和矿物质的酶标志物。将在T4和T8处获得的值与基线进行比较。我们发现所给予的HT剂量是安全的,并且大多数情况下不影响心血管疾病,血脂,炎性标记,肝或肾功能以及电解质平衡的指标。血清铁水平保持恒定,但显着(P

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