...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Redox Biology >Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain
【24h】

Reactive oxygen species scavengers ameliorate mechanical allodynia in a rat model of cancer-induced bone pain

机译：活性氧清除剂改善癌症诱发的骨痛大鼠模型的机械性异常性疼痛

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cancer-induced bone pain (CIBP) is a frequent complication in patients suffering from bone metastases. Previous studies have demonstrated a pivotal role of reactive oxygen species (ROS) in inflammatory and neuropathic pain, and ROS scavengers exhibited potent antinociceptive effect. However, the role of spinal ROS remains unclear. In this study, we investigated the analgesic effect of two ROS scavengers in a well-established CIBP model. Our results found that intraperitoneal injection of N-tert-Butyl-α-phenylnitrone (PBN, 50 and 100 mg/kg) and 4-hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl (Tempol, 100 and 200 mg/kg) significantly suppressed the established mechanical allodynia in CIBP rats. Moreover, repeated injection of PBN and Tempol showed cumulative analgesic effect without tolerance. However, early treatment with PBN and Tempol failed to prevent the development of CIBP. Naive rats received repetitive injection of PBN and Tempol showed no significant change regarding the nociceptive responses. Finally, PBN and Tempol treatment notably suppressed the activation of spinal microglia in CIBP rats. In conclusion, ROS scavengers attenuated established CIBP by suppressing the activation of microglia in the spinal cord.
机译：癌症引起的骨痛（CIBP）是患有骨转移的患者的常见并发症。先前的研究表明，活性氧（ROS）在炎症性疼痛和神经性疼痛中具有关键作用，并且ROS清除剂具有强大的镇痛作用。但是，脊髓ROS的作用仍不清楚。在这项研究中，我们调查了两种ROS清除剂在完善的CIBP模型中的镇痛作用。我们的研究结果发现腹膜内注射N-叔丁基-α-苯基硝酮（PBN，50和100 mg / kg）和4-羟基-2,2,6,6-四甲基哌啶-1-氧基（Tempol，100和200 mg / kg）可显着抑制CIBP大鼠建立的机械性异常性疼痛。此外，反复注射PBN和Tempol表现出无镇定作用的累积镇痛作用。但是，PBN和Tempol的早期治疗未能阻止CIBP的发展。幼稚大鼠接受PBN重复注射，而Tempol在伤害感受方面无明显变化。最后，PBN和Tempol处理可显着抑制CIBP大鼠脊髓小胶质细胞的活化。总之，ROS清除剂通过抑制脊髓中的小胶质细胞活化来减弱已建立的CIBP。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号