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Future challenges in the in?vitro and in?vivo evaluation of biomaterial biocompatibility

机译：生物材料生物相容性的体外和体内评估中的未来挑战

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As the science and engineering of biomaterials continues to expand with increased emphasis on the development of nanomaterials and tissue engineering scaffolds, emphasis also must be placed on appropriate and adequate approaches to the in?vivo and in?vitro evaluation of biomaterial biocompatibility/biological response evaluation. This article presents six topic areas that should be addressed by investigators as they move forward in the development of new systems for regenerative medicine. Most certainly, there are other areas that require attention to detail and a more complete understanding of the strengths and weaknesses of various experimental approaches to biomaterial/biological response evaluation. The small number of issues addressed in this article is only meant to bring to the attention of prospective investigators and authors, the importance of the development of adequate and appropriate evaluation techniques that address the unique features of biomaterials utilized in the development of new medical devices.
机译：随着生物材料科学和工程学的不断发展，对纳米材料和组织工程支架的开发越来越重视，还必须将重点放在采用适当和适当的方法进行生物材料生物相容性/生物反应评价的体内和体外评价中。 。本文介绍了研究人员在开发再生医学新系统时应解决的六个主题领域。最肯定的是，还有其他领域需要注意细节，并且需要对生物材料/生物反应评估的各种实验方法的优缺点进行更全面的了解。本文中涉及的少数问题仅是要引起准研究人员和作者的注意，即开发适当和适当的评估技术的重要性，这些评估技术应解决在开发新医疗设备时使用的生物材料的独特特征。

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