Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency

Raymond T Lee; Mitchell Bamberger; Pamela Ellsworth

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Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency

机译：米拉贝隆缓释片对膀胱过度活动症伴尿急性尿失禁，尿急和尿频的影响

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Abstract: Overactive bladder is a highly prevalent disorder with a significant impact on quality of life. Antimuscarinic agents are commonly used, but persistence is limited due to unsatisfactory efficacy and/or tolerability. Mirabegron is the first beta-3 adrenoceptor agonist approved for the treatment of overactive bladder syndrome. This paper reviews the pharmacology, mechanism of action, efficacy, and safety of mirabegron. A PubMed search of all English articles pertaining to mirabegron was performed. An alternative to antimuscarinics, mirabegron has a unique mechanism, improves overactive bladder symptoms and quality of life, and has limited adverse effects and few contraindications.

机译：摘要：膀胱过度活动症是一种高度流行的疾病，对生活质量产生重大影响。通常使用抗毒蕈碱剂，但是由于疗效和/或耐受性不佳，持久性受到限制。 Mirabegron是首个获准用于治疗膀胱过度活动症的β-3肾上腺素受体激动剂。本文综述了米拉贝隆的药理作用，作用机理，疗效和安全性。在PubMed中搜索了与mirabegron相关的所有英语文章。米拉贝隆是抗毒蕈碱药物的替代品，具有独特的机制，改善膀胱过度活动症症状和生活质量，不良反应有限，禁忌症很少。

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《Research and Reports in Urology》 |2013年第2期|共11页
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Raymond T Lee; Mitchell Bamberger; Pamela Ellsworth;
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中图分类泌尿科学（泌尿生殖系疾病）;
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1. Mirabegron, a beta-adrenoceptor agonist for the potential treatment of urinary frequency, urinary incontinence or urgency associated with overactive bladder. [J] . Tyagi P, Tyagi V IDrugs: the investigational drugs journal . 2010,第10期

机译：Mirabegron，一种β肾上腺素受体激动剂，可用于治疗膀胱过度活动症的尿频，尿失禁或尿急。
2. Mirabegron escalation to 50?mg further improves daily urgency and urgency urinary incontinence in Asian patients with overactive bladder [J] . Chun-Hou Liao, Hann-Chorng Kuo Journal of the Formosan Medical Association =: Taiwan yi zhi . 2019,第3期

机译：Mirabegron升高至50？mg可进一步改善亚洲膀胱过度活动症患者的每日尿急和尿急尿失禁
3. The overactive bladder-symptom composite score: a composite symptom score of toilet voids, urgency severity and urge urinary incontinence in patients with overactive bladder. [J] . Zinner N, Harnett M, Sabounjian L, The Journal of Urology . 2005,第5期

机译：膀胱过度活动症症状综合评分：膀胱过度活动症患者的厕所排尿，尿急程度和急迫性尿失禁综合症状评分。
4. Development of A Wearable Microwave Bladder Monitor for the Management and Treatment of Urinary Incontinence [C] . F. Krewer, F. Morgan, E. Jones, Radar sensor technology XVIII . 2014

机译：用于尿失禁治疗和治疗的可穿戴式微波膀胱监测仪的研制
5. Calcium(II)-activated potassium(I) channels in urinary bladder smooth muscle: Functional role and potential as therapeutic targets for overactive bladder. [D] . Soder, Rupal Pandey. 2012

机译：膀胱平滑肌中的钙（II）活化钾（I）通道：功能作用和潜力作为膀胱过度活动症的治疗靶标。
6. Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence urgency and frequency [O] . Raymond T Lee, Mitchell Bamberger, Pamela Ellsworth 2013

机译：米拉贝隆缓释剂对膀胱过度活动症伴尿急性尿失禁尿急和尿频的影响
7. PUK19 Cost-Effectiveness of Fesoterodine and Tolterodine for the Treatment of Overactive Bladder with Urge Urinary Incontinence in Spain and Finland [O] . Angulo J., Rejas J., Linden K., 2013

机译：在西班牙和芬兰，PUK19的非索罗定和托特罗定治疗膀胱过度活动症伴尿急性尿失禁的成本-效果

Impact of mirabegron extended-release on the treatment of overactive bladder with urge urinary incontinence, urgency, and frequency

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