The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum

Marianne Patricia Ntsama epse Foh Mengo; Giampietro Corradin; Silayuv Bongfen

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The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum

机译：伯氏疟原虫和恶性疟原虫环子孢子（CSP）的免疫应答和（Nt + Ct）蛋白混合物的影响评估

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Malaria infection is initiated when an infected Anopheline mosquito injects sporozoites during a blood meal. The Circumsporozoite (CSP) protein is the major surface protein of plasmodium sporozoites and forms a dense coat on the parasite?s surface. Although, the C-terminal (Ct) portion or side of the CSP protein has been extensively studied as a malaria candidate vaccine, little is known about the N-terminal (Nt) portion and the mixture of the 2 portions (Nt + Ct) of this protein on the immune response. Our data suggest that the mixture (Nt + Ct) peptides responded well and much more better inhibition of invasion of hepatocytes was given by the use of that mixture than when Ct or Nt was used separately. The 2 peptides seem to play an important inhibitory role against the invasion of hepatocytes by sporozoites.

机译：当感染的按蚊蚊在进餐时注射子孢子时，就会开始疟疾感染。环子孢子（CSP）蛋白是疟原虫子孢子的主要表面蛋白，在寄生虫的表面形成致密的被膜。尽管已经广泛研究了CSP蛋白的C末端（Ct）部分或侧面作为疟疾候选疫苗，但对N末端（Nt）部分和这两个部分（Nt + Ct）的混合物知之甚少这种蛋白质对免疫反应的影响。我们的数据表明，混合物（Nt + Ct）肽反应良好，与单独使用Ct或Nt相比，使用该混合物可更好地抑制肝细胞的侵袭。这两种肽似乎对子孢子侵袭肝细胞具有重要的抑制作用。

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《Research Journal of Biological Sciences》 |2008年第12期|共6页
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Marianne Patricia Ntsama epse Foh Mengo; Giampietro Corradin; Silayuv Bongfen;
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1. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge. [J] . S Chatterjee, M Wery, P Sharma, Infection and immunity . 1995,第11期

机译：恶性疟原虫环子孢子蛋白和抗肽抗体的保守肽序列抑制伯氏疟原虫子孢子侵袭Hep-G2细胞，并保护免疫小鼠免受伯氏疟原虫子孢子攻击。
2. Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and DEC-CSP in non human primates. [J] . Tewari K, Flynn BJ, Boscardin SB, Vaccine . 2010,第45期

机译：在非人类灵长类动物中，Poly（I：C）是有效的佐剂，用于抗体和多功能CD4 + T细胞对恶性疟原虫环子孢子蛋白（CSP）和DEC-CSP的反应。
3. Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and alpha DEC-CSP in non human primates. [J] . Tewari K., Flynn B. J., Boscardin S. B., Vaccine . 2010,第45期

机译：在非人类灵长类动物中，Poly（I：C）是一种有效的佐剂，可用于抗体和多功能CD4 + T细胞对恶性疟原虫环子孢子蛋白（CSP）和αDEC-CSP的应答。
4. Identification and quantitation of Plasmodium falciparum and Anopheles gambiae proteins from Plasmodium parasite infected mosquitoes [C] . Raghothama Chaerkady, Mobolaji Okulate, Kumaran Kandasamy, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：来自疟原虫感染蚊子的疟原虫和anophelesGambiae蛋白的鉴定和定量。
5. 1. Generation and characterization of mutants in the proteolytic processing site of the circumsporozoite protein (CSP) of Plasmodium berghei. 2. Fluorescent Plasmodium berghei sporozoites and pre-erythrocytic stages: A new tool to study mosquito and mammalian host interactions with malaria parasites. [D] . Natarajan, Ramya. 2006

机译：1.伯氏疟原虫环子孢子蛋白（CSP）的蛋白水解加工位点中突变体的产生和表征。 2.伯氏疟原虫子孢子荧光体和促红细胞生成前阶段：研究蚊子和哺乳动物宿主与疟原虫相互作用的新工具。
6. Poly(I:C) is an effective adjuvant for antibody and multi-functional CD4+ T cell responses to Plasmodium falciparum circumsporozoite protein (CSP) and αDEC-CSP in Non Human Primates [O] . Kavita Tewari, Barbara J. Flynn, Silvia B. Boscardin, -1

机译：poly（i：c）是对非人最新产物的抗体和多功能CD4 + T细胞反应的有效佐剂对疟原虫是恶性疟原虫环孢子蛋白（CSP）和αdec-csp的反应
7. A conserved peptide sequence of the Plasmodium falciparum circumsporozoite protein and antipeptide antibodies inhibit Plasmodium berghei sporozoite invasion of Hep-G2 cells and protect immunized mice against P. berghei sporozoite challenge [O] . S Chatterjee, M Wery, P Sharma, 1995

机译：疟原虫植入疟原虫蛋白质和抗肽抗体的保守肽序列抑制苯乙烯孢子素侵袭Hep-G2细胞的侵袭，并保护免疫小鼠免受P. Berghei孢子挑战的攻击
8. Immune Response Gene Regulation of Immunity to Plasmodium berghei sporozoites and Circumsporozoite Protein Vaccines [R] . Hoffman, S. L., Berzofsky, J. A., Isenbarger, D., 1989

机译：伯氏疟原虫子孢子和环子孢子蛋白疫苗免疫的免疫应答基因调控

The Evaluation of the Immune Response and the Effects of the Mixture of (Nt + Ct) Proteins of the Circumsporozoite (CSP) of Plasmodium berghei and Plasmodium falciparum

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