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首页> 外文期刊>Research Reports in Clinical Cardiology >Relationship between plasma apolipoprotein B concentrations and LDL particle number
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Relationship between plasma apolipoprotein B concentrations and LDL particle number

机译：血浆载脂蛋白B浓度与LDL颗粒数之间的关系

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Abstract: Many subjects with relatively normal, or even optimal, levels of low-density lipoprotein cholesterol (LDL-C) have increased atherogenic lipoprotein particle concentrations (apolipoprotein B [apoB] and LDL particle number [LDL-P] determined by nuclear magnetic resonance spectroscopy [NMR]). Numerous analyses have demonstrated that apoB and LDL-P predict the risk of future cardiovascular events more robustly than LDL-C, as estimated using the Friedewald equation. Little is known about the relationship between an individual's apoB and LDL-P level, and whether the relationship is comparable at different levels of LDL-C. The aim of this study was to examine the correlation between plasma apoB and LDL-P levels and specifically to evaluate the heterogeneity of LDL-P at low levels of apoB (< the 20th population percentile [78 mg/dL]). Data were derived from a group of consecutive patients added to a large, single laboratory database (LipoScience, Inc.) during a 1-week period in which a standard lipid profile, apoB, and LDL-P levels were available. When risk categories were assigned to the subjects using the Framingham Offspring Study's population percentiles for apoB and LDL-P, there was good agreement between the two measures when LDL-C levels were high (≥160 mg/dL). However, among individuals with low LDL-C and apoB, NMR analysis could identify a subgroup of individuals with potentially greater cardiovascular risk, as suggested by unexpected elevations in LDL-P.
机译：摘要：许多受试者的低密度脂蛋白胆固醇（LDL-C）水平相对正常，甚至达到最佳水平，致动脉粥样硬化脂蛋白颗粒浓度（通过核磁共振测定的载脂蛋白B [apoB]和LDL颗粒数[LDL-P]）增加光谱[NMR]）。大量分析表明，如使用Friedewald方程所估计的那样，apoB和LDL-P预测的未来心血管事件的风险比LDL-C预测的更可靠。关于一个人的apoB和LDL-P水平之间的关系，以及在不同的LDL-C水平下这种关系是否可比，人们所知甚少。这项研究的目的是检查血浆载脂蛋白B与LDL-P水平之间的相关性，尤其是评估低载脂蛋白B（<20％百分位数[78 mg / dL]）下LDL-P的异质性。数据来自一组连续的患者，这些患者在一个标准的脂质谱，apoB和LDL-P水平可用的1周时间内，已添加到大型单一实验室数据库（LipoScience，Inc.）中。当使用弗雷明汉后代研究针对apoB和LDL-P的人群百分位数将风险类别分配给受试者时，当LDL-C水平较高（≥160mg / dL）时，两种测量方法之间存在良好的一致性。但是，在低LDL-C和apoB低的个体中，NMR分析可以识别出可能具有更高心血管风险的个体亚组，这是LDL-P意外升高所暗示的。

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