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首页> 外文期刊>Reproductive Biology and Endocrinology >Antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) are the predictors of natural fecundability have similar trends irrespective of fertility status and menstrual characteristics among fertile and infertile women below the age of 40 years
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Antral follicle count (AFC) and serum anti-Müllerian hormone (AMH) are the predictors of natural fecundability have similar trends irrespective of fertility status and menstrual characteristics among fertile and infertile women below the age of 40 years

机译：40岁以下的可育和不育妇女的生育能力状况和月经特征，无论是生育状况还是月经特征，窦性卵泡计数（AFC）和血清抗苗勒氏激素（AMH）都是自然受孕的预测指标具有相似的趋势

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Despite being born with a significant number of primordial cells which representing the ancestor cells of the germ-line, women experience a depletion of ovarian reserve and sub-fertility mid-way into their healthy lives. The poor ovarian response is a substantial limiting factor amplified with higher maternal age and associated with a considerably lower likelihood of pregnancy. A present analytical prospective cross-sectional study was conducted to explore whether infertile women below the age of 40?years have low ovarian reserve than fertile women of same age, assessed by Antral follicle count (AFC) and anti-Müllerian hormone (AMH), at tertiary care infertility center: Lahore Institute of Fertility and Endocrinology, Hameed Latif Hospital. The study population including 423 infertile and 388 fertile female patients from June 2013 to November 2016. Patients and controls were aged between 25 and 39?years. Serum levels of FSH, LH, AMH were assessed, and AFC was measured by transvaginal sonography on cycle days 2 or 3. A total of 35.6% of infertile women stated a menstrual cycle length shorter than 21?days, while 21% had a regular cycle length between 24 and 38?days, and 43.2%, longer than 38?days. Overall, the two cohorts did not significantly differ on cycle length. The age-specific reduction of the ovarian reserve was similar in both cohorts; serum AMH concentration decreased by 6% (95% Cl: 5–8%) and AFC decline by 4.5% (95% Cl: 5–7%) per year with increased age. Aged patients (36–39?years) had a 5.3% (95% Cl, 1.5; 7.2) higher risk ratio of having an AMH level??0.7?ng/ml than women of younger age groups (Kruskal-Wallis test, p??0.01). This study indicates that the possible common observation of low respondent in ART might not be a result of over-representation of patients with an early age-specific decline in the ovarian reserve, but rather primarily as a consequence of age-specific depletion in the stock of developing follicles at the time of recruitment and selection.
机译：尽管女性天生具有代表生殖系祖先细胞的大量原始细胞，但她们在健康生活中途会经历卵巢储备的枯竭和亚生育力。卵巢反应差是一个重要的限制因素，随着更高的产妇年龄而增加，并且与怀孕的可能性大大降低有关。进行了一项目前的分析性前瞻性横断面研究，以探讨是否通过40岁以下的不育女性的卵巢储备能力低于同龄的可育女性，通过肛门卵泡计数（AFC）和抗苗勒管激素（AMH）评估在三级医疗不育中心：Hameed Latif医院拉合尔生育与内分泌研究所。自2013年6月至2016年11月，研究人群包括423名不育和388名可育女性患者。患者和对照组的年龄在25至39岁之间。在第2或第3天评估血清FSH，LH，AMH的水平，并通过阴道超声检查AFC。总共35.6％的不育妇女表示月经周期短于21天，而21％的月经周期正常。周期长度在24到38天之间，占43.2％，比38天更长。总体而言，两个队列在周期长度上没有显着差异。在这两个队列中，特定年龄段卵巢储备的减少相似。随着年龄的增长，血清AMH浓度每年下降6％（95％Cl：5-8％），AFC下降4.5％（95％Cl：5-7％）。老年患者（36-39岁）的AMH水平 0.7？ng / ml的风险率比年轻年龄组的女性高5.3％（95％Cl，1.5; 7.2）（Kruskal-Wallis检验， p≤0.01。这项研究表明，可能普遍观察到抗逆转录病毒治疗低应答的原因可能不是卵巢储备的早期特定年龄下降的患者过多代表的结果，而是主要是由于种群中特定年龄消耗的结果募集和选择时发育中的卵泡的变化。

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