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In vitro anti-arthritic activity of vitex negundo and punica granatum

机译：荆条和石榴的体外抗关节炎作用

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The aim of present study is to evaluate the in vitro anti arthritic activity of aqueous and ethanolic extract of Vitex negundo and Punica granatum by Bovine serum albumin and egg albumin denaturation method. The activity of aqueous and ethanolic extract of Vitex negundo and Punica granatum was compared with standard Anti -arthritic drug Diclofenac Sodium. Results revealed that the ethanolic extract of Punica granatum at a different concentration possessed significant anti- arthritis activity as compare to std. drug. The current finding exhibited a concentration dependent inhibition of protein (egg albumin and BSA) denaturation by aqueous and Ethanolic extract of Vitex negundo and Punica granatum. The effect of Diclofenac Sodium was found to be approximate when compared with the Punica granatum at (800-g/ml). In denaturation method egg albumin, at concentration of 100, 200, 400 and 800-g/ml, ethanolic extraction of Vitex negundo showed 40.11%, 58.05%, 63.43% and 87.52% respectively. Whereas, ethanolic extraction of Punica granatum showed 50.28%, 101.71%, 187.75%, 261.08%. In Bovine Serum albumin denaturation method at concentration of 100, 200, 400 and 800-g/ml, ethanolic extraction of Vitex negundo showed 20.03%, 42.72%, 59.06%, 72.08% respectively. Whereas, Ethanolic extraction of Punica granatum showed 28.54%, 42.88%, 81.39%, 99.18% of inhibition. From the present finding it can be concluded that Punica granatum possessed maximum anti-arthritic effect against denaturation of protein invitro. The effect was possibly due to flavonoids, Alkaloids, terpenoids content of Punica granatum.
机译：本研究的目的是通过牛血清白蛋白和蛋清蛋白变性方法评价黄荆和石榴的水提取物和乙醇提取物的体外抗关节炎活性。将荆条和石榴的水和乙醇提取物的活性与标准抗关节炎药双氯芬酸钠进行了比较。结果表明，与标准品相比，不同浓度的石榴籽乙醇提取物具有明显的抗关节炎活性。药品。目前的发现显示了荆条和石榴的水和乙醇提取物对蛋白质（例如白蛋白和BSA）变性的浓度依赖性抑制。与浓度为（800-g / ml）的石榴相比，双氯芬酸钠的作用是近似的。在变性方法中，卵白蛋白的浓度分别为100、200、400和800-g / ml，用乙醇提取黄荆条分别为40.11％，58.05％，63.43％和87.52％。而乙醇提取的石榴皮分别为50.28％，101.71％，187.75％，261.08％。在浓度分别为100、200、400和800-g / ml的牛血清白蛋白变性方法中，用酒糟提取的Vitex negundo分别占20.03％，42.72％，59.06％，72.08％。而乙醇提取的石榴皮表现出28.54％，42.88％，81.39％，99.18％的抑制率。从目前的发现可以得出结论，石榴属植物具有对抗蛋白质体外变性的最大抗关节炎作用。该作用可能是由于石榴中的类黄酮，生物碱，萜类化合物含量所致。

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