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首页> 外文期刊>Research Journal of Pharmaceutical Sciences >A comparative analysis of UV-visible spectroscopic method vs HPLC method for determining content assay of ciprofloxacin 500 MG tablets
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A comparative analysis of UV-visible spectroscopic method vs HPLC method for determining content assay of ciprofloxacin 500 MG tablets

机译：紫外可见光谱法与高效液相色谱法测定环丙沙星500 MG片含量的比较分析

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Ciprofloxacin tablets are usually prescribed in GIT infections particularly in typhoid. In Pakistan there are several brands of ciprofloxacin available with different trade names in local market. The standard method of determining the amount of active ingredient present in tablets described by US Pharmacopeia is HPLC method. This study was conducted to compare the results of analysis of UV-visible spectroscopic method and HPLC method to determine the amount of ciprofloxacin (active) present in different brands. Content assay was performed by these two methods. Other tests like weight variation, hardness, disintegration and dissolution test were performed on all brands under study. For this study eight brands of ciprofloxacin were purchased from local market of Islamabad and evaluated on the basis of above mentioned tests according to compendial methods. Results showed that all brands complied with USP specifications for all parameters. UV-visible spectroscopic method showed reliable and comparable results to that of HPLC method so this can provide a reliable method for assay of the drug as that of compendial method HPLC.
机译：通常在胃肠道感染（尤其是伤寒）中开具环丙沙星片剂。在巴基斯坦，环丙沙星的几种品牌在当地市场上都有不同的商标名称。美国药典描述的测定片剂中活性成分含量的标准方法是HPLC方法。进行了这项研究，以比较紫外可见光谱法和HPLC法测定不同品牌中环丙沙星（活性成分）的分析结果。通过这两种方法进行含量测定。在所研究的所有品牌上都进行了其他测试，例如重量变化，硬度，崩解和溶出度测试。对于该研究，从伊斯兰堡的当地市场购买了八种环丙沙星品牌，并根据上述方法根据药典方法对其进行了评估。结果表明，所有品牌的所有参数均符合USP规范。紫外可见光谱法显示了与HPLC方法可靠且可比的结果，因此，与药典方法HPLC相比，这可以提供一种可靠的药物测定方法。

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