Pharmacokinetic assessment of transdermal patch loaded with solid dispersions of tenoxicam

lakshmi K. Muni Raja; Jyothi B. Jeevana

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Pharmacokinetic assessment of transdermal patch loaded with solid dispersions of tenoxicam

机译：载有替诺昔康固体分散体的透皮贴剂的药代动力学评估

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Tenoxicam (TNX), synthetic NSAID indicated for the therapy of rheumatoid arthritis and to relief acute pain. It has poor solubility. Solubility of tenoxicam was enhanced by formulation of solid dispersions. To assess whether solubility is increased or not, the present research work is aimed to estimate the in-vivo plasma concentration of patch with solid dispersions of tenoxicam and patch loaded with pure tenoxicam using RP-HPLC method. Pharmacokinetic parameters like Cmax, t1/2, and AUC0-24 of patch made with solid dispersions of tenoxicam were found to be 2.131.

机译：Tenoxicam（TNX），合成的NSAID，用于治疗类风湿关节炎和缓解急性疼痛。它的溶解性差。通过配制固体分散体可以增强替诺昔康的溶解度。为了评估溶解度是否增加，本研究工作旨在使用RP-HPLC方法估算具有替诺昔康固体分散体的贴剂和负载纯替诺昔康的贴剂的体内血浆浓度。发现使用替诺昔康固体分散体制成的贴剂的药代动力学参数（如Cmax，t1 / 2和AUC0-24）为2.131。

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《Research Journal of Pharmaceutical Sciences》 |2019年第2期|共5页
作者
lakshmi K. Muni Raja; Jyothi B. Jeevana;
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中图分类药学;
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Tenoxicamtransdermal patchpharmacokinetic assessment;

机译：替诺昔康透皮贴剂药代动力学评估;

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Pharmacokinetic assessment of transdermal patch loaded with solid dispersions of tenoxicam

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