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首页> 外文期刊>Research Journal of Medical Sciences >Light and Scanning Microscopic Study of the Effect of Car Fuel (Gasoline) Inhalation on Guinea Pig Respiratory System at Station
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Light and Scanning Microscopic Study of the Effect of Car Fuel (Gasoline) Inhalation on Guinea Pig Respiratory System at Station

机译：车站吸入汽车燃料（汽油）对豚鼠呼吸系统影响的光和扫描显微镜研究

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Exposures to gasoline vapor among workers had hazards impact on pulmonary function and structure. This study was designed to evaluate the effect of outdoor exposure to gasoline vapor on trachea and lung of guinea pigs. Twenty five animals were divided into control (A) and experimental (B). The experimental group was subjected to gasoline inhalation at station for 30 (B1) and 90 (B2) days. Those exposed for 30 days were subdivided into two subgroups; one received ascorbic acid during exposure (B1a) and the other did not receive it (B1b). Trachea, using light and scanning microscope visualized shortening and even loss of cilia as well as focal epithelial desquamation resulted from exposure to gasoline vapor. Significant decrease in tracheal goblet cells occurred due to gasoline inhalation (90 days). Both mucosa and submucosa showed cellular infiltration. Exposure of lung to gasoline vapor (30 days) resulted in focal inflammatory cell infiltrate, intra-alveolar hemorrhage and focal emphysematous changes. Alveolar septum thickening and accumulation of intra-alveolar exudate was observed in 90 days exposed animals. Bronchi showed elongation of the mucosal fold, sloughing of some epithelial cells and accumulation of secretions. Inflammatory cell infiltration appeared in the wall of both bronchi and bronchioles. Animals received vitamin C during exposure to gasoline vapor had less histopathological changes in both trachea and lung. Gasoline vapor had adverse effect on histological structure of lungs and trachea, which could be partially ameliorated by vitamin C supplement.
机译：工人接触汽油蒸气会对肺功能和结构产生危害。这项研究旨在评估户外暴露于汽油蒸气对豚鼠气管和肺的影响。将25只动物分为对照（A）和实验（B）。实验组在车站接受汽油吸入30（B1）和90（B2）天。那些暴露了30天的人被分为两个亚组。一个人在暴露过程中接受抗坏血酸（B1a），另一个人则不接受抗坏血酸（B1b）。气管，用光和扫描显微镜观察，由于暴露于汽油蒸气而导致的纤毛缩短甚至消失，以及局灶性上皮脱皮。吸入汽油（90天）导致气管杯状细胞明显减少。粘膜和粘膜下层均显示细胞浸润。肺暴露于汽油蒸汽中（30天）导致局灶性炎性细胞浸润，肺泡内出血和局灶性气肿改变。在暴露90天的动物中观察到肺泡间隔增厚和肺泡内渗出物积聚。支气管显示粘膜皱褶伸长，一些上皮细胞脱落和分泌物积聚。支气管和细支气管壁均出现炎性细胞浸润。在接触汽油蒸气期间接受维生素C的动物在气管和肺部的组织病理学变化较小。汽油蒸气对肺和气管的组织结构有不利影响，补充维生素C可以部分改善。

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