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首页> 外文期刊>Research Journal of Medical Sciences >Assessment of the Drug Storage Facilities and Quality of Generic Co-Formulation Tablets (Stavudine, Lamivudine, Nevirapine) at HIV/AIDS Treatment Centers in Uganda
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Assessment of the Drug Storage Facilities and Quality of Generic Co-Formulation Tablets (Stavudine, Lamivudine, Nevirapine) at HIV/AIDS Treatment Centers in Uganda

机译：在乌干达艾滋病毒/艾滋病治疗中心评估药物共混片剂（司他夫定，拉米夫定，奈韦拉平）的药物贮存设施和质量

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摘要

This study investigated the storage facilities and the quality of Co-formulation tablets containing stavudine, lamivudine and nevirapine at four treatment centers in Uganda. A cross-sectional survey of drug storage conditions at four distribution centers randomly selected from four regions of Uganda was done using a checklist developed from the guideline for good drug storage practices. Drug batches were sampled at the time of the survey and one month after storage and analyzed for quality using appearance, uniformity of weight, dissolution rate and drug content. All treatment centers had satisfactory storage design but lacked facilities for monitoring temperature and humidity. Air-conditioning facilities were also lacking. Batches investigated had average weight deviation of less than 5%; content of active pharmaceutical ingredients lay between 90-110% and the dissolution rate was greater than 80% in 45 min both on delivery and after one month of storage. The quality of co-formulation tablets containing stavudine, lamivudine and nevirapine was of good quality. However, the storage facilities at the HIV/Aids treatment centers were inadequate. They need to be provided with facilities to monitor temperature and humidity as the antiretroviral programme expands to cover a broader spectrum of drugs.
机译：这项研究调查了在乌干达的四个治疗中心中含有司他夫定，拉米夫定和奈韦拉平的复方片剂的储存设施和质量。根据乌干达四个地区随机选择的四个配送中心的药品储存条件进行了横断面调查，该清单是根据良好药品储存规范指南制定的清单。在调查时和储存后一个月对药物批次进行采样，并使用外观，重量均匀性，溶出度和药物含量对质量进行分析。所有处理中心的存储设计均令人满意，但缺乏监控温度和湿度的设施。也缺乏空调设施。所调查的批次的平均重量偏差小于5％;活性药物成分的含量介于90-110％之间，并且在交货后和储存一个月后的45分钟内溶出度均大于80％。包含司他夫定，拉米夫定和奈韦拉平的复合制剂的质量良好。但是，艾滋病毒/艾滋病治疗中心的储存设施不足。随着抗逆转录病毒计划的扩展以涵盖更广泛的药物种类，它们需要配备有监测温度和湿度的设施。

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