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The Use of NeuroAiD (MLC601) in Postischemic Stroke Patients

机译：NeuroAiD（MLC601）在缺血性中风患者中的使用

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Aim. We aimed to assess the efficacy of MLC601 on functional recovery in patients given MLC601 after an ischemic stroke.Methods. This is a retrospective cohort study comparing poststroke patients given open-label MLC601 (n=30; 9 female) for three months and matching patients who did not receive MLC601 from our Stroke Data Bank. Outcome assessed was modified Rankin Scale (mRS) at three months and analyzed according to: (1) achieving a score of 0-2, (2) achieving a score of 0-1, and (3) mean change in scores from baseline.Results. At three months, 21 patients on MLC601 became independent as compared to 17 patients not on MLC601 (OR 1.79; 95% CI 0.62–5.2;P=0.29). There were twice as many patients (n=16) on MLC601 who attained mRS scores similar to their prestroke state than in the non-MLC601 group (n=8) (OR 3.14; 95% CI 1.1–9.27;P=0.038). Mean improvement in mRS from baseline was better in the MLC601 group than in the non-MLC601 group (−1.7 versus −0.9; mean difference −0.73; 95% CI −1.09 to −0.38;P<0.001).Conclusion. MLC601 improves functional recovery at 3 months postischemic stroke. An ongoing large randomized control trial of MLC601 will help validate these results.
机译：目标。我们旨在评估MLC601对缺血性中风后服用MLC601的患者功能恢复的疗效。这是一项回顾性队列研究，比较接受开放标签MLC601（n = 30; 9名女性）三个月的卒中后患者与未从我们的卒中数据库中接受MLC601的患者进行匹配。在三个月时对评估的结果进行改良的Rankin量表（mRS）并根据以下内容进行分析：（1）得分为0-2，（2）得分为0-1，（3）得分相对于基线的平均变化。结果。在三个月的时间里，有21位接受MLC601的患者变得独立，而没有接受MLC601的有17位患者（OR 1.79; 95％CI 0.62-5.2; P = 0.29）。在MLC601上获得与中风前状态相似的mRS评分的患者（n = 16）是非MLC601组（n = 8）的两倍（OR 3.14; 95％CI 1.1–9.27; P = 0.038）。 MLC601组的mRS相对于基线的平均改善比非MLC601组更好（-1.7对-0.9;平均差-0.73; 95％CI -1.09至-0.38; P <0.001）。 MLC601可改善缺血性卒中后3个月的功能恢复。正在进行的MLC601大型随机对照试验将有助于验证这些结果。

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